Tuan Vo-Dinh, left, and Molly Gregas are researchers at Duke University. (Credit: Duke University Photography)
Modelling the neuron as little more than a simple on/off switch is a big mistake (Image: Dan Webber)
Metaphase in a human cervical carcinoma (HeLa) cell. Chromosomes (red), microtubules (green). (Credit: Jason Swedlow, University of Dundee)
Image: Death of a tumor: This PET scan, taken just days after radiation therapy, shows a hot spot of cell-death activity in a brain tumor--a good indication that the therapy is working. Credit: Aaron Allen, Davidoff Comprehensive Cancer Center, Rabin Medical Center 
Image: Cellular transformation: A cocktail of three genes can transform skin cells into neurons (shown here in red). Credit: Thomas Vierbuchen 
Lee Rubin, director of translational medicine at HSCI and the other senior author on the research team, said that "our goals were to try to as discretely and specifically as possible guide the cells through the deprogramming process" from the adult state to the embryonic-like state. (Credit: Photograph by Kris Snibbe/Harvard Staff Photographer)
Professor Justin St John, who has left the UK for Australia (left); Sir Leszek Borysiewicz, of the MRC, which turned down one licence-holder (right). REX
Figure 1. A 53-year-old patient experiencing sporadic discomfort undergoes a coronary angiogram. The results are ominous. Severe stenosis (narrowing) is visible in the pinched regions (top middle), indicating the buildup of fatty deposits within the artery. If a wandering clot blocks the pinhole opening of a nearly clogged vessel, a heart attack ensues. With bloodflow blocked, cardiac cells downstream are starved for oxygen, leading to drastic metabolic changes as the cells struggle to survive. The most important changes affect mitochondria, the powerhouses of cell metabolism. The inset shows mitochondria (orange) arrayed among cardiac muscle fibrils (blue), where they are positioned to supply a steady stream of ATP to contracting muscle. Under oxidative stress, the mitochondria can also release potent effectors that lead directly to apoptosis—cell suicide. The trigger for the opening of the so-called mitochondrial death channels is, ironically, the return of oxygen to starved tissue during reperfusion. Learning to control the activities of the death channels could vastly improve the outlook for heart attack victims.
Cell-to-cell variability in clathrin-mediated endocytosis (green signal) is determined by local cell density. (Credit: Image courtesy of ETH Zurich)
Collections of a few protocells connected by shared membranes penetrated by pores (a) can be used in groups to perform as electronic devices (b), in this case as a rectifier, or AC to DC converter. (Image: Nature)
Shown in green are genetically-corrected fibroblasts from Fanconi anemia patients are reprogrammed to generate induced pluripotent stem cells, which, in turn, can be differentiated into disease-free hematopoietic progenitors, capable of producing blood cells in vitro. (Credit: Courtesy of Dr. Juan-Carlos Belmonte, Salk Institute for Biological Studies)
Image: An embryo treated with RNA interference to delay the onset of cell polarization. At the beginning of the process, P granules (green) have already nearly completely dissolved throughout the embryo. However, when the embryo ultimately polarizes, the polarity protein PAR-2 (red) appears on the posterior cortex, and P granules reform by condensation in the vicinity of this posterior region. Credit: Clifford Brangwynne (Credit: Image courtesy of Marine Biological Laboratory)
Rat neuron with a micropipette inserting mRNAs directly onto the cell. After laser photoporation the mRNA goes into the cell and the TIPeR-induced changes in cell phenotype are initiated. (Credit: Chia-wen Wu, PhD and James Eberwine, PhD University of Pennsylvania School of Medicine)
Computer-rendered image of human organs. New research suggests that bioengineered replacement organs may be closer thanks to a newly developed matrix on which stem cells can form a three-dimensional organ. (Credit: iStockphoto/Sebastian Kaulitzki)
This photo, provided by ProtoLife, shows vesicles, artificial membranes for cells, made from scratch. Teams around the world, including ProtoLife, are trying to create synthetic life in a lab. Martin Hanczyc / AP
Pleodorina starrii has an incomplete division of labor. Although the 12 small cells near the top of this colony only swim, the 20 larger cells both swim and reproduce. (Credit: Copyright 2008 Matthew Herron)
