After Years Of Search, Breakthrough Discoveries Of Alzheimer's Genes

Karen Kasmauski / Science Faction / Corbis

From Time Magazine:

Fifteen years since the last discovery of its kind, scientists have finally identified a new set of genes that may contribute to Alzheimer's disease.

The three new genes, known as clusterin, complement receptor 1 (CR1) and PICALM, were uncovered by two separate research groups, one in Wales and one in France, who linked the genes to the most common form of the memory disorder, late-onset Alzheimer's — the type that affects patients in their 60s or later and accounts for about 90% of all Alzheimer's cases. The only other gene connected with the condition, apolipoprotein E (ApoE), was identified in 1993; since, researchers have tirelessly hunted for other key genes, knowing that 60% to 80% of the progressive, incurable disease is genetically based.

Read more ....