Scientists Identify A Key Protein That May Explain The Anti-Aging And Anti-Cancer Benefits of Dietary Restriction

From The Next Big Future:

High nutrients activate HIF-1 through the TOR-S6K pathway, which leads to increased ER stress and shortened lifespan. Other regulators such as PHA-4, SKN-1, AAK-2, DAF-16 and HSF-1 may function in parallel to HIF-1 to modulate DR-induced longevity phenotypes.

A protein that plays a key role in tumor formation, oxygen metabolism and inflammation is involved in a pathway that extends lifespan by dietary restriction.

The finding, which appears in the May 22, 2009 edition of the on-line journal PLoS Genetics, provides a new understanding of how dietary restriction contributes to longevity and cancer prevention and gives scientists new targets for developing and testing drugs that could extend the healthy years of life.

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