What Does a Drug That Extends Life In Mice Mean For Humans?

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From Time Magazine:

A natural compound, used as an immunosuppressant in organ-transplant patients, has been found to extend life in mice, according to a study published Wednesday by the journal Nature. Aging mice that were given the substance, rapamycin, lived significantly longer than mice that didn't get the drug: females that received rapamycin were 13% older at death, and males 9% older.

The research, conducted as part of the National Institute of Aging Interventions Testing Program, took place at three separate test sites and involved nearly 2,000 genetically similar mice. Trials began when mice were about 600 days old — well into middle age, at a stage roughly equivalent to 60-year-old humans.

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Update: Secret to a longer life lies on Easter Island -- The Independent

Finding Fear: Neuroscientists Locate Where It Is Stored In The Brain

For the first time, neuroscientists have located the neurons responsible for fear conditioning in the mammalian brain. (Credit: iStockphoto/Kurt Paris)

From Science Daily:

ScienceDaily (July 8, 2009) — Fear is a powerful emotion, and neuroscientists have for the first time located the neurons responsible for fear conditioning in the mammalian brain. Fear conditioning is a form of Pavlovian, or associative, learning and is considered to be a model system for understanding human phobias, post-traumatic stress disorder and other anxiety disorders.

Using an imaging technique that enabled them to trace the process of neural activation in the brains of rats, University of Washington researchers have pinpointed the basolateral nucleus in the region of the brain called the of amygdala as the place where fear conditioning is encoded.

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My Comment: Inhibit the fear .... you will have the ultimate soldier.

Laughter: Not Just For Funny Stuff

Laughter comes in two main types, scientists found. Credit: Dreamstime

From Live Science:

Scientists say there are two types of laughter: the kind that comes from pure glee, and the kind that's meant to send a social message. New research suggests autistic children don't often express the latter type, a finding that could reveal more about the nature of human laughter.

Laughter probably predates human speech by millions of years, scientists think. It likely evolved as an early form of communication to help people negotiate group dynamics and establish hierarchy, said William Hudenko, a psychologist at Ithaca College who led the new study.

Babies usually learn to laugh before they learn to speak.

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Europe Targets Manned Spaceship

From The BBC:

Europe has taken the first step towards building its own manned spaceship.

The European Space Agency has asked industry to work out the requirements of the craft and its likely cost.

Known as the Advanced Re-Entry Vehicle, it would be developed in phases - first as an unmanned vessel to carry cargo, and then as an astronaut crew ship.

At the moment, Europe has no independent capability to transport humans into space and must hitch rides on American or Russian systems.

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Google Announces PC Operating System To Compete With Windows

From Epicenter/Wired:

Google is releasing a lightweight, open-source PC-operating system later this year, the company announced Tuesday night, a move that threatens the very heart of Microsoft, long seen as Google’s biggest rival.

Chrome OS is intended to be a very lightweight, quick-starting operating system whose central focus is supporting Google’s Chrome browser. Applications will run mostly inside the browser, making the web — not the desktop — into the computer’s default operating system.

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Was Ancient Earth A Green Planet?

From The New Scientist:

Earth's landmasses in the late Precambrian probably weren't pleasant, but at least they were green. A new analysis of limestone rocks laid down between 1 billion and 500 million years ago suggests that there was extensive plant life on land much earlier than previously thought.

The plants were only tiny mosses and liverworts, but they would have had a profound effect on the planet. They turned the hitherto barren Earth green, created the first soils and pumped oxygen into the atmosphere, laying the foundations for animals to evolve in the Cambrian explosion that started 542 million years ago.

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Scientists Create 'Artificial Brain Cell'

From The Telegraph:

Scientists have created an artificial brain cell they believe could one day be used to treat devastating neurological diseases.

The team has managed to pass messages within the mind in the same way as nerve cells, using a tiny piece of plastic which can transmit electricity.

These messages are used by the brain to control many actions in the body.

Correcting when they go awry could be the key to treating some diseases like Parkinson's disease researchers believe.

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Archaeologists Dive Deep Into The Lost World Of The Maya

From USA Today:

CARA BLANCA, Belize — Machete chops echo and leaves rustle underfoot when the vines clear, revealing cobalt-blue water in a cliff-sided pool.

Hidden beneath the dry-season forest, these waters, the blue cenotes (cen-NO-tays) of Cara Blanca, represent a mystery for scholars, one left by the ancient Maya. What lies within these sacred wells?

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My Comment: A compelling and a must read on Mayan history.

Human Sperm Created From Stem Cells In World First, Claims British University

From The Telegraph:

British scientists have created human sperm using stem cells in a medical first that could revolutionise fertility treatment, they claim.

Researchers at the pioneering Northeast England Stem Cell Institute say they have made the breakthrough using stem cells from an embryo.

They claim that with some minor changes the sperm could theoretically fertilise an egg to create a child.

Within 10 years, the scientists say the technique could also be used to allow infertile couples to have children that are genetically their own. It could even be possible to create sperm from female stem cells, they say, which would ultimately mean a woman having a baby without a man.

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New Evidence That Vinegar May Be Natural Fat-fighter

Found in many salad dressings, pickles, and other foods, vinegar could help prevent accumulation of body fat and weight gain, scientists report. (Credit: Wikimedia Commons)

From Science Daily:

ScienceDaily (July 7, 2009) — Researchers in Japan are reporting new evidence that the ordinary vinegar — a staple in oil-and-vinegar salad dressings, pickles, and other foods — may live up to its age-old reputation in folk medicine as a health promoter. They are reporting new evidence that vinegar can help prevent accumulation of body fat and weight gain.

Tomoo Kondo and colleagues note in the new study that vinegar has also been used as a folk medicine since ancient times. People have used it for a range of ills. Modern scientific research suggests that acetic acid, the main component of vinegar, may help control blood pressure, blood sugar levels, and fat accumulation.

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Humans Ate Fish 40,000 Years Ago

Chinese fishermen haul in the catch of fish from the frozen Chagan Lake in Songyuan, northeast China's Jilin province on December 25, 2008, at the start of the winter fishing season. Chagan Lake covers an area of 259 square kilometers and is one of the 10 largest freshwater lakes in China, where each winter, fishermen use the ancient method of breaking the ice with wooden stakes before placing their nets to harvest the fish. Getty Images

From Live Science:

At least one of our ancestors regularly ate fish 40,000 years ago, a new study finds.

Scientists analyzed chemical compositions of the protein collagen in an ancient human skeleton from Tianyuan Cave near Beijing to reach their conclusion.

Fishing at this time must have involved considerable effort, the researchers think, because fossil records suggest humans were not using sophisticated tools — beyond crude stone blades — until about 50,000 years ago.

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Ray Kurzweil on How to Combat Aging

From Technology Review:

The noted futurist says that exponential advances will allow us to intervene in the aging process.

Submitted in response to Technology Review's interview with Leonard Hayflick. See "Can Aging Be Solved?"

Entropy is not the most fruitful perspective from which to view aging. There are varying error rates in biological information processes depending on the cell type, and this is part of biology's paradigm. We have means already of determining error-free DNA sequences even though specific cells will contain DNA errors, and we will be in a position to correct those errors that matter.

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Stephen Hawking: "Humans Have Entered A New Stage Of Evolution"

From The Daily Galaxy:

Although It has taken homo sapiens several million years to evolve from the apes, the useful information in our DNA, has probably changed by only a few million bits. So the rate of biological evolution in humans, Stephen Hawking points out in his Life in the Universe lecture, is about a bit a year.

"By contrast," Hawking says, "there are about 50,000 new books published in the English language each year, containing of the order of a hundred billion bits of information. Of course, the great majority of this information is garbage, and no use to any form of life. But, even so, the rate at which useful information can be added is millions, if not billions, higher than with DNA."

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Coffee 'May Reverse Alzheimer's'

From The BBC:

Drinking five cups of coffee a day could reverse memory problems seen in Alzheimer's disease, US scientists say.

The Florida research, carried out on mice, also suggested caffeine hampered the production of the protein plaques which are the hallmark of the disease.

Previous research has also suggested a protective effect from caffeine.

But British experts said the Journal of Alzheimer's disease study did not mean that dementia patients should start using caffeine supplements.

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Buzz Aldrin: Why We Should Leave The Moon Alone And Settle Mars Instead

Photo: Buzz Aldrin is pictured standing on the moon,
which Neil Armstrong can be seen reflected in his visor.

From The Daily Mail:

Nasa astronaut Buzz Aldrin, the second man to walk on the Moon, has urged the world to forget about returning to our nearest satellite and head to Mars instead.

'Why do we want to go to go back to the Moon?' he asked.

'Some nations want to go for prestige to say they are 'first' in space exploration in the 21st century and they want Nasa to compete with them.

'But there's no reason for us to go back. We can look at the effects of long-term missions in space by flying around comets, rather than setting up a base on the Moon. We're not going to launch any missions from there.'

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Reasons Not to Panic Over a Painkiller

From The New York Times:

Few drugs are more ubiquitous than acetaminophen, the pain reliever found in numerous over-the-counter cold remedies and the headache drug Tylenol.

But last week, a federal advisory committee raised concerns about liver damage that can occur with overuse of acetaminophen, and the panel even recommended that the Food and Drug Administration ban two popular prescription drugs, Vicodin and Percocet, because they contain it.

The news left many consumers confused and alarmed. Could regular use of acetaminophen for pain relief put them at risk for long-term liver damage?

To help resolve the confusion, here are some questions and answers about acetaminophen.

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How Can YouTube Survive?

Brand of the free: Founder Jawed Karim appeared in the first video, of elephants at a zoo

From The Independent:

It's wildly popular - and thought to be losing hundreds of millions of dollars a year. Now questions are being asked about the future of YouTube. Rhodri Marsden investigates a mystery of digital-age 'freeconomics'

It must surely rank as the most mundane business launch in history. Jawed Karim, one of the founders of YouTube, shuffles timidly in front of a video camera while standing in front of a group of elephants at San Diego zoo, with precious little idea of what he was starting. "The cool thing about these guys," he says, nervously gesturing behind him, "is that they have really long trunks. And that's pretty much all there is to say."

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Caffeine Reverses Memory Impairment In Mice With Alzheimer's Symptoms

Coffee drinkers may have another reason to pour that extra cup. When aged mice bred to develop symptoms of Alzheimer's disease were given caffeine -- the equivalent of five cups of coffee a day -- their memory impairment was reversed. (Credit: iStockphoto/Royce DeGrie)

From Science Daily:

ScienceDaily (July 6, 2009) — Coffee drinkers may have another reason to pour that extra cup. When aged mice bred to develop symptoms of Alzheimer's disease were given caffeine – the equivalent of five cups of coffee a day – their memory impairment was reversed, report University of South Florida researchers at the Florida Alzheimer's Disease Research Center.

Back-to-back studies published online July 6 in the Journal of Alzheimer's Disease, show caffeine significantly decreased abnormal levels of the protein linked to Alzheimer's disease, both in the brains and in the blood of mice exhibiting symptoms of the disease. Both studies build upon previous research by the Florida ADRC group showing that caffeine in early adulthood prevented the onset of memory problems in mice bred to develop Alzheimer's symptoms in old age.

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How Global Catastrophe Could Make Us Smarter

From Live Science:

When supervolcanoes blow their tops, the world's climate is altered and life is snuffed out regionally and challenged globally. Such an event is thought to have occurred 74,000 years ago when the Toba supervolcano erupted in what is now Sumatra with a force estimated to be 1,000 to 10,000 times that of Mount St. Helens.

The timing of Toba's tempest fits with an interesting bottleneck known to exist in human evolution, as seen in DNA evidence. The population became very small sometime between 90,000 and 60,000 years ago. And a new idea floating around suggests that the eruption may have contributed — by necessity — to our supreme intelligence today. Further, it has been suggested, we may be undergoing the next great leap in smarts right now.

More on all that lower down. First, some fresh research on the eruption:

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Coming Soon: Photographic Memory In A Pill?

RGS-14: Will you remember what this protein looks like 2 months from now?

From Popsci.com:

Scientists isolate a protein that significantly increases visual recall.

Wish you had a photographic memory? Well, Encyclopedia Brown, drugs may amp your brain up to that point soon. A group of Spanish scientists claim to have singled out a protein that can extend the life of visual memory significantly. When the production of the protein was boosted in mice, the rodents' visual memory retention increased, from about an hour to almost 2 months.

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