Combined Stem Cell-Gene Therapy Approach Cures Human Genetic Disease In Vitro

Shown in green are genetically-corrected fibroblasts from Fanconi anemia patients are reprogrammed to generate induced pluripotent stem cells, which, in turn, can be differentiated into disease-free hematopoietic progenitors, capable of producing blood cells in vitro. (Credit: Courtesy of Dr. Juan-Carlos Belmonte, Salk Institute for Biological Studies)

From Science Daily:

ScienceDaily (June 1, 2009) — A study led by researchers at the Salk Institute for Biological Studies, has catapulted the field of regenerative medicine significantly forward, proving in principle that a human genetic disease can be cured using a combination of gene therapy and induced pluripotent stem (iPS) cell technology. The study is a major milestone on the path from the laboratory to the clinic.

"It's been ten years since human stem cells were first cultured in a Petri dish," says the study's leader Juan-Carlos Izpisúa Belmonte, Ph.D., a professor in the Gene Expression Laboratory and director of the Center of Regenerative Medicine in Barcelona (CMRB), Spain. "The hope in the field has always been that we'll be able to correct a disease genetically and then make iPS cells that differentiate into the type of tissue where the disease is manifested and bring it to clinic."

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Bing It: Microsoft To Launch New Search Engine But Doesn't Bank On Beating Google

From The Daily Mail:

Microsoft has unveiled a new search engine in a bid to lure Web surfers away from Google and other search sites.

It is hoped that new site, 'Bing', will be more successful than the company's two most recent incarnations: Live Search and MSN Search.

Microsoft claims the new search engine will offer an improvement in the number of users who actually find answers to their search questions.

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Why Is The Earth Moving Away From The Sun?

Photo: The sun and Earth are moving apart by about 15 cm per year - the culprit may be tides raised on the sun by our home planet (Image: NASA)

From New Scientist:

Skywatchers have been trying to gauge the sun-Earth distance for thousands of years. In the third century BC, Aristarchus of Samos, notable as the first to argue for a heliocentric solar system, estimated the sun to be 20 times farther away than the moon. It wasn't his best work, as the real factor is more like 400.

By the late 20th century, astronomers had a much better grip on this fundamental cosmic metric – what came to be called the astronomical unit. In fact, thanks to radar beams pinging off various solar-system bodies and to tracking of interplanetary spacecraft, the sun-Earth distance has been pegged with remarkable accuracy. The current value stands at 149,597,870.696 kilometres.

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Robots Rolling Towards Farm Revolution

A 3D laser ranging view of a Pennsylvania apple orchard can not only allow a mobile robot to pace its rows, but also captures detail of every tree, its foliage and fruit. This image was produced using techniques developed by Daniel Munoz, Martial Hebert and Nicolas Vandapel (Image: Nicolas Vandapel)

From The New Scientist:

From ploughs to seed drills to tractors, evolving technology has brought about radical changes to agriculture over the years. Now the sector is poised for another shift as robotic farmhands gear up to make agriculture greener and more efficient.

Three things now make mobile agricultural robots a real possibility in the near future, says Tony Stentz, an engineer at Carnegie Mellon University's robotics institute.

Firstly, mobile robots have now proved able to cope with complex outdoor environmentsMovie Camera; secondly, the price of production has fallen; and, finally, society should now see robot labourers as a benefit not a curse.

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U.N.’s ‘Global Warming=300,000 Deaths A Year’ Report – Kofi Annan Implies: “Close Enough For Government Work”

From Watts Up With That?

Many of you have probably heard by now of the UN. Report saying that “global warming is killing 300,000 people a year”. There’s a Times Online Story (h/t to Gary Boden) about it today that has some startling admissions. Here are some excerpts:

Climate change is already killing 300,000 people a year in a “silent crisis” that is seriously affecting hundreds of millions more, an influential humanitarian group warned today.

A report by the Global Humanitarian Forum, led by Kofi Annan, the former UN Secretary-General, says that the effects of climate change are growing in such a way that it will have a serious impact on 600 million people, almost ten per cent of the world’s population, within 20 years. Almost all of these will be in developing countries.

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Slide Show: Top 10 Earth- and People-Friendly Buildings

GISH APARTMENTS--SAN JOSE, CALIF.: A building's environmental impact doesn't have to stop at its threshold. That's why the Gish Apartments are steps from a local light rail and have a convenience store downstairs, so residents don't have to jump in their cars to pick up that gallon of milk or get to work.

To turn a San Jose brownfield into mixed housing for low-income and special-needs families, First Community Housing, a local affordable housing organization, turned to locally based OJK Architecture and Planning to create the 35-unit structure. Although some of the building materials—such as double-glazed windows and rooftop solar panels—were pricier to purchase at the outset, they're already being offset by cheaper operational costs. BERNARD ANDRE PHOTOGRAPHY

From Scientific America:

The American Institute of Architects pick their top examples of building projects that marry form and function for both human and environmental needs

Can a building be as easy on the environment as it is on the eyes? Without a doubt, says The American Institute of Architects (AIA), a professional association based in Washington, D.C. To prove it, for the past 12 years, the organization and its Committee on the Environment (COTE) have awarded the top 10 green projects across the globe.

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How Oxidative Stress May Help Prolong Life

Trey Ideker, Ph.D. is a researcher at University of California, San Diego.
(Credit: UC San Diego)

From Science Daily:

ScienceDaily (May 30, 2009) — Oxidative stress has been linked to aging, cancer and other diseases in humans. Paradoxically, researchers have suggested that small exposure to oxidative conditions may actually offer protection from acute doses. Now, scientists at the University of California, San Diego, have discovered the gene responsible for this effect.

Their study, published in PLoS Genetics on May 29, explains the underlying mechanism of the process that prevents cellular damage by reactive oxygen species (ROS).

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Scientists Reveal the Secret to Hockey's Wrist Shot

From Live Science:

It takes less than a second, but the wrist shot in hockey is one of the hardest skills in sports to master. Just ask the Pittsburgh Penguins and the Detroit Red Wings who will face each other starting this weekend in the National Hockey League's Stanley Cup Finals. Both teams know the value of the "quick wrister" and the scoring chances it creates. Now, a team of Canadian (of course) researchers believe they have isolated the key components of a successful wrist shot using 3-D motion capture analysis.

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My Comment: Never could master the wrist shot .... ended up playing goal tender in my teenage years.

An Update On What’s Happening With Fusion Research.

From Classical Values:

Nature News is reporting that the ITER fusion experiment is in big trouble. Very big trouble. It is way over budget, way behind time, and the experimental efforts are being scaled back.

ITER -- a multi-billion-euro international experiment boldly aiming to prove atomic fusion as a power source -- will initially be far less ambitious than physicists had hoped, Nature has learned.

Faced with ballooning costs and growing delays, ITER's seven partners are likely to build only a skeletal version of the device at first. The project's governing council said last June that the machine should turn on in 2018; the stripped-down version could allow that to happen (see Nature 453, 829; 2008). But the first experiments capable of validating fusion for power would not come until the end of 2025, five years later than the date set when the ITER agreement was signed in 2006.

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Is America's Space Administration Over-the-Hill? Next-Gen NASA

From Popular Mechanics:

It has been 40 years since NASA first placed man on the moon. Not only was the space agency still young, but most of its employees were fresh out of college. Today, less than 20 percent of NASA's employees are under the age of 40, leading one report to call the agency "mono-generational." This leads to a disturbing question: As the baby boomers retire, who will get astronauts back to the lunar surface?

Thick sideburns, clean-cut but full heads of hair and fresh-looking faces framed by chunky, black glasses. That was NASA of the 1960s. Considering all the flag-waving young celebrants, the photos of Mission Control just after Apollo 11 safely parachuted into the Pacific on July 24, 1969, could be mistaken for a Fourth of July frat party. You can't help but think they look a bit young to be sending men to the moon. Compared to NASA today, they were.

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Unusual Neuron Could ExplainTthe Smartest Species

Killer Whales: NOAA/Robert Pittman

From Popsci.com:

People have it, elephants have it, even killer whales have it

A neuroscientist carves up brains to investigate the presence of unique brain cells found only in humans, primates, elephants and a handful of marine mammals -- species that are characterized by large brains, a long childhood spent learning from their elders, and sophisticated social interaction, reports Smithsonian.

In his Caltech lab, John Allman slices off the thinnest slivers of an elephant's brain, looking for the presence of von Economo neurons -- and possibly a glimpse into the evolution of human behavior.

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Ancient Volcanic Eruptions Caused Global Mass Extinction

Researchers believe they have uncovered evidence of a giant volcanic eruption that led to global mass extinction 260 million years ago. (Credit: iStockphoto/James Steidl)

From Science Daily:

ScienceDaily (May 30, 2009) — A previously unknown giant volcanic eruption that led to global mass extinction 260 million years ago has been uncovered by scientists at the University of Leeds.

The eruption in the Emeishan province of south-west China unleashed around half a million cubic kilometres of lava, covering an area 5 times the size of Wales, and wiping out marine life around the world.

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Why We'll Always Fear Snakes

From Live Science:

My daughter has a snake, a tiny 8-inch-long, innocuous corn snake, and I hate that thing.

I have seen it, and once, in the name of pretending to be a good mother, I actually touched it. But I hope to never see or touch it again as long as I live.

As an anthropologist, I know that most people around the globe hate snakes (and yes, I know there are people like my daughter who love these disgusting reptiles, but really, they are freaks, all of them except my daughter). The fear of snakes is called ophidiophobia, which is apparently a subset of herpetophobia, the more inclusive fear of reptiles. Although ophidiophobia might seem like a pathology — how often, really, do we encounter poisonous snakes? — anthropologist Lynn Isbell of the University of California, Davis, suggests in her new book "The Fruit, The Tree, and the Serpent: Why We See So Well" (Harvard University Press, 2009) that this fear is not only part of our nature, it's also a good thing.

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NASA Extends Contract With Russia For Trips To Space Station

ESA Photo Gallery / ISS
Copyright: NASA, ESA and Others

From RIA Novosti:

WASHINGTON, May 29 (RIA Novosti) - NASA has signed a $306 million deal with Russia's Federal Space Agency Roscosmos extending the current contract for transporting crew to the International Space Station.

The deal covers four Soyuz launches - two in spring 2012, and another two in fall 2012. It provides for post-flight rehabilitation of crewmembers, limited cargo transit to the ISS, and trash disposal.

NASA said in a statement on its website on Thursday that the contract modification also includes "comprehensive Soyuz support, including all necessary training and preparation for launch, crew rescue, and landing of a long-duration mission for six individual station crew members."

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US Lab Debuts Super Laser

A US weapons lab pulled back the curtain on a
super laser with the power to burn as hot as a star

From AFP:

SAN FRANCISCO (AFP) — A US weapons lab on Friday pulled back the curtain on a super laser with the power to burn as hot as a star.

The National Ignition Facility's main purpose is to serve as a tool for gauging the reliability and safety of the US nuclear weapons arsenal but scientists say it could deliver breakthroughs in safe fusion power.

"We have invented the world's largest laser system," actor-turned-governor Arnold Schwarzenegger said during a dedication ceremony attended by thousands including state and national officials.

"We can create the stars right here on earth. And I can see already my friends in Hollywood being very upset that their stuff that they show on the big screen is obsolete. We have the real stuff right here."

NIF is touted as the world's highest-energy laser system. It is located inside the Lawrence Livermore National Laboratory about an hour's drive from San Francisco.

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Hurricane Barriers Floated To Keep Sea Out Of NYC

From AP:

NEW YORK (AP) — When experts sketch out nightmare hurricane scenarios, a New York strike tends to be high on the list.

Besides shaking skyscrapers, a major hurricane could send the Atlantic Ocean surging into the nation's largest city, flooding Wall Street, subways and densely packed neighborhoods.

As a new hurricane season starts Monday, some scientists and engineers are floating an ambitious solution: Barriers to choke off the surging sea and protect flood-prone areas.

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Six Things Science Has Revealed About The Female Orgasm

From The New Scientist:

This week we report on the continuing debate about female ejaculation: is it real, and if so why does it happen?

See Everything you always wanted to know about female ejaculation (but were afraid to ask)

Ejaculation is just one of the aspects of female sexuality that are being demystified by research. In particular, the female orgasm, the subject of so many myths and folk beliefs, is gradually being understood.

Following some intense field research, here are some of the key facts about the female orgasm, as revealed by modern science.

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Sun Cycle 'Lowest Since 1928'

From NASA:

May 29, 2009: An international panel of experts led by NOAA and sponsored by NASA has released a new prediction for the next solar cycle. Solar Cycle 24 will peak, they say, in May 2013 with a below-average number of sunspots.

"If our prediction is correct, Solar Cycle 24 will have a peak sunspot number of 90, the lowest of any cycle since 1928 when Solar Cycle 16 peaked at 78," says panel chairman Doug Biesecker of the NOAA Space Weather Prediction Center.

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Flipping The Brain's Addiction Switch Without Drugs

Researchers have found a naturally occurring protein that gets rats addicted with no drugs at all. From left: BYU grad student David Allison, BYU psychology professor Scott Steffensen, and recent graduate Micah Hansen, who co-authored the research as an undergraduate. (Credit: Image courtesy of Brigham Young University)

From Science Daily:

ScienceDaily (May 29, 2009) — When someone becomes dependent on drugs or alcohol, the brain's pleasure center gets hijacked, disrupting the normal functioning of its reward circuitry.

Researchers investigating this addiction "switch" have now implicated a naturally occurring protein, a dose of which allowed them to get rats hooked with no drugs at all.

The research will be published Friday in the journal Science.

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Test Tube Babies On the Rise Worldwide

From Live Science:

More than 200,000 babies were born worldwide with the help of in vitro fertilization and other reproductive technologies in 2002, with a 25 percent increase between 2000 and 2002, according to a new report.

However, the "Octomom" aside, multiple births resulting from assisted reproductive technologies (ART) have been on the decline, with Europe and Australia-New Zealand leading the way in the reduction of multiples, say the scientists responsible for the report published online today in the journal Human Reproduction.

(Multiple births, rather than being seen as a success, are considered a serious medical complication with potentially harmful effects for both babies and mom.)

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