UV Radiation, Not Vitamin D, Might Limit Multiple Sclerosis Symptoms

From Science News:

Sunshine effects on MS might be more complicated than previously thought, mouse study suggests.

Ultraviolet radiation from sunshine seems to thwart multiple sclerosis, but perhaps not the way most researchers had assumed, a new study in mice suggests.

If validated in further research, the finding could add a twist to a hypothesis that has gained credence in recent decades. The report appears online March 22 in the Proceedings of the National Academy of Sciences.

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Multiple Sclerosis 'Blood Blockage Theory' Tested

Image: The answer may lie with blood flow

From The BBC:

US scientists are testing a radical new theory that multiple sclerosis (MS) is caused by blockages in the veins that drain the brain.

The University of Buffalo team were intrigued by the work of Italian researcher Dr Paolo Zamboni who claims 90% of MS is caused by narrowed veins.

He says the restricted drainage, visible on scans, injures the brain leading to MS.

He has already widened the blockages in a handful of patients.

The US team want to replicate his earlier work before treating patients.

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W5 Investigates Intriguing New Theory About MS

Dr. Paolo Zamboniis seen at his research lab at the University of Ferrara.

From CTV News:

A group of doctors in Italy is investigating a fascinating new treatment for multiple sclerosis, based on a theory that, if proven true, could radically alter the lives of patients.

An investigation by CTV's W5 reveals that this treatment appears to stop the disease from progressing. Patients seen in the documentary relate how, after the simple procedure, their MS symptoms suddenly stopped and, in some cases, they were able to resume normal lives.

The Italian research is asking fundamental questions about the origins of the debilitating condition, whose causes have long remained a mystery.

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Multiple Sclerosis Successfully Reversed In Mice: New Immune-suppressing Treatment Forces The Disease Into Remission

Dr. Jacques Galipeau of the Jewish General Hospital Lady Davis Institute for Medical Research and McGill University. (Credit: Claudio Calligaris/McGill University)

From Science Daily:

ScienceDaily (Aug. 12, 2009) — A new experimental treatment for multiple sclerosis (MS) completely reverses the devastating autoimmune disorder in mice, and might work exactly the same way in humans, say researchers at the Jewish General Hospital Lady Davis Institute for Medical Research and McGill University in Montreal.

MS is an autoimmune disease in which the body's own immune response attacks the central nervous system, almost as if the body had become allergic to itself, leading to progressive physical and cognitive disability.

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Stem Cell Transplant Reverses Early Stage Multiple Sclerosis

From Eureka Alert:

CHICAGO --- Researchers from Northwestern University's Feinberg School of Medicine appear to have reversed the neurological dysfunction of early-stage multiple sclerosis patients by transplanting their own immune stem cells into their bodies and thereby "resetting" their immune systems.

"This is the first time we have turned the tide on this disease," said principal investigator Richard Burt, M.D. chief of immunotherapy for autoimmune diseases at the Feinberg School. The clinical trial was performed at Northwestern Memorial Hospital where Burt holds the same title.

The patients in the small phase I/II trial continued to improve for up to 24 months after the transplantation procedure and then stabilized. They experienced improvements in areas in which they had been affected by multiple sclerosis including walking, ataxia, limb strength, vision and incontinence. The study will be published online January 30 and in the March issue of The Lancet Neurology.

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