Temporarily Reversing Aging In The Immune System?

Researchers have discovered a new mechanism controlling aging in white blood cells. The research opens up the possibility of temporarily reversing the effects of aging on immunity and could, in the future, allow for the short-term boosting of the immune systems of older people. (Credit: © nyul / Fotolia)

Possibility of Temporarily Reversing Aging in the Immune System -- Science Daily

ScienceDaily (Aug. 16, 2011) — Researchers have discovered a new mechanism controlling aging in white blood cells. The research, published in the September issue of the Journal of Immunology, opens up the possibility of temporarily reversing the effects of aging on immunity and could, in the future, allow for the short-term boosting of the immune systems of older people.

Weakened immunity is a serious issue for older people. Because our immune systems become less effective as we age we suffer from more infections and these are often more severe. This takes a serious toll on health and quality of life.

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Tested: A Reboot For The Immune System

Reset Immune System iStock

From Popular Science:

The ability to reprogram the immune system is one of the most sought-after goals in medicine. Now researchers are closer than ever to pulling it off in patients with Type 1 diabetes, one of whom happens to be our correspondent.

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'Missing Link' In Immune Response To Disease: Sheer Mechanical Force

A highly focused laser beam (at right) is used to apply mechanical force (shown as a double headed arrow) to a microsphere (white) coated with histocompatibility protein. The microsphere abuts the surface of a single T cell, shown in gray (top). Activation of the T cell is measured by a change in calcium levels within the cell, which are shown by green colorization (left, prior to force application; bottom, after force application). The direction of force must be tangential, rather than perpendicular, to the T cell surface in order to trigger a rise in calcium levels. Without an application of force, the binding of the histocompatibility protein produces no such rise. (Credit: Please credit Dana-Farber Cancer Institute)

From Science Daily:

Science Daily (Nov. 10, 2009) — The immune system's T cells have the unique responsibilities of being both jury and executioner. They examine other cells for signs of disease, including cancers or infections, and, if such evidence is found, rid them from the body. Precisely how T cells shift so swiftly from one role to another, however, has been a mystery.

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Fibre Boosts Immune System, Study Finds

Fibre-rich foods may keep you regular and protect against bowel cancer, but they help boost the immune system too Australian research has found. Credit: iStockphoto

From Cosmos:

SYDNEY: An apple a day may keep the doctor away but a fibre-filled diet could also hold the key to keeping asthma, diabetes and arthritis at bay, according to Australian research released Thursday.

Scientists at Sydney's Garvan Institute of Medical Research say that fibre not only helps keep people regular, it boosts the immune system so it can better combat inflammatory diseases.

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In Shaping Our Immune Systems, Some 'Friendly' Bacteria May Play Inordinate Role

A little-known bacterial species called segmented filamentous bacterium, or SFB, can activate the production of specialized immune cells in mice. This scanning electron microscope image of an SFB colony shows a mass of long hair-like filaments created when the bacteria stay attached to each other after they divide. (Credit: Ivaylo Ivanov and Dan Littman (NYU Langone Medical Center) and Doug Wei (Carl Zeiss SMT, Inc.))

From Science Daily:

ScienceDaily (Oct. 19, 2009) — Out of the trillions of "friendly" bacteria -- representing hundreds of species -- that make our intestines their home, new evidence in mice suggests that it may be a very select few that shape our immune responses. The findings detailed in two October 16th reports appearing in the journals Cell and Immunity, both Cell Press publications, offer new insight into the constant dialogue that goes on between intestinal microbes and the immune system, and point to a remarkably big role for a class of microbes known as segmented filamentous bacteria (SFB).

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Flu Vaccines Hit A Wall

Photo: Attacking influenza: Scientists hope that new technologies for making vaccines will lead to quicker availability of vaccines against the human strain of H1N1 that originated from the swine flu virus, shown here. Credit: CDC

From Technology Review:

As new influenza strains emerge, researchers struggle to speed vaccine development.

Making a vaccine against seasonal influenza is a constant catch-up game. Scientists must predict which of the constantly mutating virus strains will be most virulent six months in the future, the amount of time it takes to manufacture the vaccine. The system has worked well enough for the regular flu. But when new, virulent strains emerge--including the current, rapidly spreading swine flu (H1N1)--the traditional approach falls short. Even as consumers clamored for a vaccine, it took seven months and around 48,000 confirmed U.S. cases before the first H1N1 vaccines were shipped to hospitals around the country.

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Blood Counts Are Clues To Human Disease

From Science Daily:

Science Daily (Oct. 12, 2009) — A new genome-wide association study published October 11 in Nature Genetics begins to uncover the basis of genetic variations in eight blood measurements and the impact those variants can have on common human diseases. Blood measurements, including the number and volume of cells in the blood, are routinely used to diagnose a wide range of disorders, including anaemia, infection and blood cell cancers.

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Caught On Video: Immune Cell Destroys Bacteria

Confocal microscope image showing insect immune cells (green) containing fluorescently labeled E.coli (red). Credit: University of Bath

From Live Science:

In a starring role for E. coli, researchers have developed a new technique to make movies of bacteria as they infect their victims and are consumed by the host's immune cells.

The movies mark the first time that scientists have been able to look at bacteria infecting living organisms in real time, according to the researchers. Most studies of bacterial infections are preformed after the host has died.

The scientists, from the University of Bath and the University of Exeter in the UK, tested out their movie-making method on developing fruit fly embryos. They injected fluorescently tagged bacteria into the embryos and observed how the microbes interacted with the insect's immune cells, called hemocytes, using time-lapse confocal microscopy, an imaging technique. They used two types of bacteria for the study Escherichia coli and Photorhabdus asymbiotica.

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Extraordinary IImmune Cells May Hold The Key To Managing HIV

From Science Daily:

ScienceDaily (Dec. 5, 2008) — People who manage to control HIV on their own are providing scientists with valuable information about how the immune system eliminates virus-infected cells. A new study identifies specific characteristics of the immune cells that successfully destroy HIV-infected cells and may drive strategies for developing the next generation of HIV vaccines and therapies.

Long-term nonprogressors (LTNPs) or elite controllers are rare individuals who are able to contain HIV for many years without any type of antiretroviral therapy. "Direct and indirect lines of evidence in humans and animal models suggest that virus-specific immune cells, called CD8+ T cells, mediate this control. However, the mechanisms by which this occurs remain unknown," says senior study author Dr. Mark Connors from the National Institute of Allergy and Infectious Disease in Bethesda, Maryland.

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