Chemists Win Nobel Prize For Atom-by-Atom Ribosome Map

The Ribosome

From Popular Science:

Rounding out the 2009 science Nobel Prizes are Venkatraman Ramakrishnan, Thomas A. Steitz, and Ada E. Yonath, who will receive the prize in chemistry for their work on an atomic-scale map of the ribosome.

Ribosomes are the cellular organelle responsible for assembling amino acids into proteins. If DNA is the blueprint, ribosomes are the construction workers. Ribosomes themselves are composed of a combination of RNA and specialized proteins.

Read more ....

DNA Not The Same In Every Cell Of Body: Major Genetic Differences Between Blood And Tissue Cells Revealed

New research calls into question one of the most basic assumptions of human genetics: that when it comes to DNA, every cell in the body is essentially identical to every other cell. (Credit: iStockphoto)

From Science Daily:

ScienceDaily (July 16, 2009) — Research by a group of Montreal scientists calls into question one of the most basic assumptions of human genetics: that when it comes to DNA, every cell in the body is essentially identical to every other cell. Their results appear in the July issue of the journal Human Mutation.

This discovery may undercut the rationale behind numerous large-scale genetic studies conducted over the last 15 years, studies which were supposed to isolate the causes of scores of human diseases.

Read more ....

DNA Is Dynamic And Has High Energy; Not Stiff Or Static As First Envisioned

New research shows that DNA is not a stiff or static as once thought.
(Credit: iStockphoto/Andrew Wood)

From Science Daily:

ScienceDaily (July 14, 2009) — The interaction represented produced the famous explanation of the structure of DNA, but the model pictured is a stiff snapshot of idealized DNA. As researchers from Baylor College of Medicine and the University of Houston note in a report that appears online in the journal Nucleic Acids Research, DNA is not a stiff or static. It is dynamic with high energy. It exists naturally in a slightly underwound state and its status changes in waves generated by normal cell functions such as DNA replication, transcription, repair and recombination.

DNA is also accompanied by a cloud of counterions (charged particles that neutralize the genetic material's very negative charge) and, of course, the protein macromolecules that affect DNA activity.

Read more ....

How Trivial DNA Changes Can Hurt Health

From Scientific American:

Small changes to DNA that were once considered innocuous enough to be ignored are proving to be important in human diseases, evolution and biotechnology.

Biologists long thought they understood how genetic mutations cause disease. But recent work has revealed an important twist in the tale and uncovered surprising—even counterintuitive—ways that alterations in DNA can make people sick. The classic view assumed that what are termed “silent” mutations were inconsequential to health, because such changes in DNA would not alter the composition of the proteins encoded by genes. Proteins function in virtually every process carried out by cells, from catalyzing biochemical reactions to recognizing foreign invaders. Hence, the thinking went, if a protein’s makeup ends up being correct, any small glitches in the process leading to its construction could not do a body harm.

Read more ....

Thousands Of 'Cold Cases' Could Be Reopened Thanks To New DNA Technique

From The Telegraph:

Thousands of "cold cases" could be reopened thanks to a new technique to analyse DNA from crime scenes.

The Forensic Science Service (FSS) hailed the breakthrough as the most significant advancement in the science "in a decade".

Scientists will now be able to use the technique in all serious crimes, after it proved successful in a series of pilots.

Police forces and forensic scientists are also combing the archives of thousands of so-called "cold cases", in which no-one has been convicted of the crime, for DNA samples which could be reassessed.

Read more ....