A New Way to Treat Diabetes?

Biologists at UC San Diego have discovered a chemical that offers a completely new and promising direction for the development of drugs to treat metabolic disorders such as type 2 diabetes -- a major public health concern in the United States due to the current obesity epidemic. (Credit: Image by Peter Allen, UC Santa Barbara)

Discovery of Chemical That Affects Biological Clock Offers New Way to Treat Diabetes -- Science Daily

ScienceDaily (July 12, 2012) — Biologists at UC San Diego have discovered a chemical that offers a completely new and promising direction for the development of drugs to treat metabolic disorders such as type 2 diabetes -- a major public health concern in the United States due to the current obesity epidemic.

Their discovery, detailed in a paper published July 13 in an advance online issue of the journal Science, initially came as a surprise because the chemical they isolated does not directly control glucose production in the liver, but instead affects the activity of a key protein that regulates the internal mechanisms of our daily night and day activities, which scientists call our circadian rhythm or biological clock.

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My Comment: A promising direction to help type 2 diabetes patients.

Type 1 Diabetes Cure?

Photo: Dr. Roger Unger (left) and Dr. Young Lee found in an animal study that blocking the hormone glucagon might eliminate the symptoms of type 1 diabetes. (Credit: Image courtesy of UT Southwestern Medical Center)

Potential 'Cure' for Type 1 Diabetes? -- Science Daily

ScienceDaily (Jan. 27, 2011) — Type 1 diabetes could be converted to an asymptomatic, non-insulin-dependent disorder by eliminating the actions of a specific hormone, new findings by UT Southwestern Medical Center researchers suggest.

These findings in mice show that insulin becomes completely superfluous and its absence does not cause diabetes or any other abnormality when the actions of glucagon are suppressed. Glucagon, a hormone produced by the pancreas, prevents low blood sugar levels in healthy individuals. It causes high blood sugar in people with type 1 diabetes.

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My Comment: Faster please .... much faster.

Diet and Exercise Trump Diabetes Drugs

From Live Science:

A news search on the word "Avandia," the diabetes drug, will pull up thousands of results, nearly all pertaining to the Food and Drug Administration's decision last week to keep this dangerous drug on the market, albeit with restrictions.

Another search on "Avandia + diet," will produce only a few results. And herein lies the problem. Too many doctors rely solely on prescription drugs to treat their patients' diabetes; and too many FDA regulators leave the concept of diet completely out of the diabetes equation.

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1 In 10 Chinese Adults Is Diabetic, Study Finds

From StlToday.com/AP:

After working overtime to catch up to life in the West, China now faces a whole new problem: the world's biggest diabetes epidemic.

One in 10 Chinese adults already have the disease and another 16 percent are on the verge of developing it, according to a new study. The finding nearly equals the U.S. rate of 11 percent and surpasses other Western nations, including Germany and Canada.

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Why Drugs Don't Help Diabetes Patients' Hearts

From Time Magazine:

Doctors at the annual meeting of the American College of Cardiology in Atlanta on Sunday got some surprising news on their first day of sessions. Researchers presented three studies revealing that some of the most widely prescribed medications to reduce the risk of heart disease in Type 2 diabetes patients appeared not to provide much benefit at all.

People with diabetes are twice as likely as nondiabetics to suffer a heart attack — most diabetes patients die of heart disease — and for years, physicians have used aggressive drug treatments to lower that risk. To that end, the goal has commonly been to lower blood sugar or control blood-sugar spikes after eating, lower triglycerides and reduce blood pressure in diabetes patients to levels closer to those of healthy, nondiabetic individuals. By using medication to treat these factors, which are linked to a higher risk of heart attack and stroke in other patients, doctors assumed they would also be reducing the risk in people with diabetes.

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Dolphins Can Turn Diabetes On … And Off

Bottlenose dolphins may gives scientists clues into how to shut off diabetes type II, and provide an insight into a range of other human ailments. Credit: U.S. National Parks Service

From Cosmos:

SAN DIEGO: Healthy bottlenose dolphins appear to turn on and off a diabetes-like state: a trick that may open to door to a treatment for the disease in humans.

The ‘switch’ mechanism, discovered by researchers at the non-profit National Marine Mammal Foundation, is likely driven by the dolphins’ high-protein, low-carbohydrate fish diet.

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Landmark DNA Study Of 3,000 People To Unlock Mystery Of Type 2 Diabetes

Type 2 diabetes, characterised by insulin resistance, can cause blindness and impotence

From Times Online:

The genetic roots of type 2 diabetes are to be explored in unprecedented depth to help to find better ways to diagnose and treat a disease that affects more than 2 million people in Britain.

A £15 million study is to read the complete DNA of 3,000 people, more than ten times more than have so far had their genomes sequenced, The Times has learnt.

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Drinking Cups Of Tea And Coffee 'Can Prevent Diabetes'

From The BBC:

Tea and coffee drinkers have a lower risk of developing type 2 diabetes, a large body of evidence shows.

And the protection may not be down to caffeine since decaf coffee has the greatest effect, say researchers in Archives of Internal Medicine.

They looked at 18 separate studies involving nearly 500,000 people.

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Diabetes Cases to Double in 25 Years

From Live Science:

If Americans don't eat better and exercise more, diabetes cases will double by 2034 and costs to care for the patients will triple, according to a new report that paints a bleak picture of the future.

With diabetes, the body fails to metabolize glucose, or blood sugar. Diabetes is the leading cause of amputations, blindness, and end-stage kidney disease.

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Myths About Diabetes And Diet Persist

From Live Science:

Once upon a time, in the dark ages of the 1960s and '70s, a diabetes diet meant avoiding sugar. Refrigerators of diabetics were filled with Fresca; sugar bowls were filled with Sweet'N Low; and, for the most part, plates were still filled with meat and potatoes.

That diet didn't work so well, and self-administered insulin shots were often needed to keep blood-sugar levels safe.

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What Are The Signs of Diabetes?

From Live Science:

This Week's Question: I've been very thirsty lately and someone mentioned to me that this
is a symptom for diabetes. Is that true?

An intense thirst is one diabetes symptom. Here are others: frequent urination, strong hunger, fatigue, unintended weight loss, slow-healing sores, dry and itchy skin, numbness or tingling in your feet, and blurred vision. However, some people with diabetes do not have symptoms.

Diabetes mellitus is a group of diseases characterized by high levels of blood sugar. Diabetes can create serious health problems, but diabetics can control the disease.

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Breakthrough In Fight Against Diabetes

From The Telegraph:

A gene that controls the way the body responds to the hormone insulin has been identified, marking a breakthrough in the fight against diabetes.

Scientists believe a variation in the gene's DNA promotes insulin resistance, the primary cause of type 2 diabetes. The disease is the most common form of diabetes, affecting around two million people in the UK.

The discovery could lead to new drug treatments that target the genetic fault and prevent the body failing to respond to insulin.

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