A Genetic Link To Autism

Photo: Researchers from the University of Washington analysed the DNA of children with autism and both of their parents Photo: ALAMY

New Genetic Link To Autism -- The Telegraph

Autistsm could develop in children with no family history of the condition due to genetic mutations which develop in older father's sperm cells, a new study shows.

Autism Spectrum Disorder (ASD) is known to be strongly influenced by genetics because it often runs in families, but which genes are at fault and how strong a role they play remains unclear.

Now three studies of autistic children who had no family history of the condition suggest it could in some cases be caused by gene mutations which are not shared by either parent and occur for the first time in sperm or egg cells as they develop.

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Flawed Autism Study Won't Stop Vaccine Critics

A medical assistant draws an MMR vaccination at the
Spanish Peaks Outreach Clinic in Walsenburg, Colo. John Moore / Getty

From Time Magazine:

More than any other research, it was a study published in British medical journal the Lancet in 1998 that helped foster the persisting notion that childhood vaccines can cause autism. On Tuesday, that flawed study, led by gastroenterologist Dr. Andrew Wakefield, was officially retracted by the journal's editors — a serious slap and rare move in the world of medicine.

"It has become clear that several elements of the 1998 paper by Wakefield et al are incorrect, contrary to the findings of an earlier investigation," wrote the Lancet editors in a statement issued online.

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Paper Linking Vaccine To Autism Retracted

There is no evidence that vaccines cause autism. Credit: iStockphoto

From Cosmos:

PARIS: Medical journal The Lancet has withdrawn a 1998 study linking autism with inoculation against three childhood illnesses, a paper that caused an uproar and an enduring backlash against vaccination.

"We fully retract this paper from the published record," The Lancet's editors said in a statement published online.

The 1998 paper suggested there might be a connection between autism and a triple vaccine for measles, mumps and rubella (MMR).

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More Evidence That Autism Is a Brain 'Connectivity' Disorder

From Science Daily:

Science Daily (Jan. 11, 2010) — Studying a rare disorder known as tuberous sclerosis complex (TSC), researchers at Children's Hospital Boston add to a growing body of evidence suggesting that autism spectrum disorders, which affect 25 to 50 percent of TSC patients, result from a miswiring of connections in the developing brain, leading to improper information flow. The finding may also help explain why many people with TSC have seizures and intellectual disabilities.

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Study Pinpoints Autism Clusters in Calif.

Image: (CBS/iStockphoto)

From CBS News:

More Cases Found in Areas where Parents are Better Educated and Near Autism Treatment Centers

(CBS) Researchers in California have identified 10 regions in the state where cases of autism are higher than in nearby regions.

The study finds that the areas, called clusters, are in places where parents have above average levels of education, or are also places located near large autism treatment facilities.

The research, conducted by scientists at UC Davis, showed that the clusters appear in highly populated areas of Southern California and the Bay Area.

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Autism Numbers Are Rising. The Question is Why? Read more

Sven Hagolani / Corbis

From Time Magazine:

One in 110 American children are considered to fall somewhere along the autism spectrum, according to the latest report released by the federal government. The new figure, which was released initially in October, comes from the most comprehensive set of data yet on the developmental health of eight-year-olds.

Increasing the previous federal estimate of 1 in 150, the new data suggest that 1% of children now exhibit some symptoms of an autism spectrum disorder (ASD), a collection of neurological conditions whose symptoms may range from mild social impairment to more serious communication, language and cognitive deficits. The estimate also represents a stunning 57% increase in prevalence since 2002, when health officials first began a nationwide effort to quantify the risk of autism in childhood.

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New Evidence That Early Therapy Helps Autistic Kids

Charlie Lamb was diagnosed with autism at age 2
Photo courtesy of the Lamb family

From Time Magazine:

Charlie Lamb was barely 2 years old when he was diagnosed with autism. His mother Susan had been convinced for months that "something was not right" with her second child. He wouldn't stand in line like the other kids in gymnastics class, she recalls, and he spoke fewer words. He was more captivated by spinning wheels than Teletubbies. His father Tom noticed that his blond, blue-eyed son would always walk in circles around the kitchen table and that he would do the equivalent at their local park in Seattle — walking along the perimeter fence rather than crossing into the play area.

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Growing Old With Autism

Noah Greenfeld, 42, who spent 15 years in a state mental facility, is now in an assisted living home near his parents in Los Angeles. Max S. Gerber for TIME

From Time Magazine:

Noah, my younger brother, does not talk. Nor can he dress himself, prepare a meal for himself or wipe himself. He is a 42-year-old man, balding, gaunt, angry and, literally, crazy. And having spent 15 years at the Fairview Developmental Center in Costa Mesa, Calif., a state facility, Noah has picked up the con's trick of lashing out before anyone could take a shot at him.

Noah's autism has been marked by "three identified high priority maladaptive behaviors that interfere with his adaptive programming. These include banging his head against solid surfaces, pinching himself and grabbing others," according to his 2004 California Department of Developmental Services individual program plan (IPP). Remarkably, that clinical language actually portrays Noah more favorably than the impression one would get from a face-to-face meeting.

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Have We Found Key To Autism? Scientists Hail 'Monumental' Breakthrough That Could Help Millions

Finding the missing piece: An autistic child during one of his regular behavioral therapy sessions contemplates a jigsaw puzzle

From The Daily Mail:

Scientists have pinpointed rogue genes that could unlock the riddle of autism.

The breakthrough has been hailed as a 'monumental achievement' that could revolutionise understanding and treatment of the condition.

Experts have compared it to the pivotal cancer research of the 1970s, which began unravelling the disease's genetic causes.

Autism and related conditions such as Asperger's syndrome affect at least one in 100 UK children, and some research puts the figure as high as one in 60. Even the lower estimate is ten times the level of 30 years ago.

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