Antibiotic-Resistant Diseases Pose 'Apocalyptic' Threat

Hospital superbugs such as MRSA are some of the best know antibiotic-resistant diseases, but MPs were warned about infections such as gonorrhea and TB that affect the general population. Photograph: Getty Images 

Antibiotic-Resistant Diseases Pose 'Apocalyptic' Threat, Top Expert Says -- The Guardian 

Chief medical officer Dame Sally Davies tells MPs issue should be added to national risk register of civil emergencies. Britain's most senior medical adviser has warned MPs that the rise in drug-resistant diseases could trigger a national emergency comparable to a catastrophic terrorist attack, pandemic flu or major coastal flooding.

 Dame Sally Davies, the chief medical officer, said the threat from infections that are resistant to frontline antibiotics was so serious that the issue should be added to the government's national risk register of civil emergencies.

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My Comment: Apocalyptic is underestimating the impact that such a development can become.

First Antibiotic-Resistant Gonorrhea Cases Detected In The U.S.

Gonorrhea infects close to 700,000 Americans each year. 

First Antibiotic-Resistant Gonorrhea Cases Detected In North America -- US News and World Report

Completely incurable gonorrhea may be at hand. 

The fears of major health organizations have come true: Gonorrhea that is immune to the last remaining effective oral antibiotic has been detected in at least nine North American patients, meaning the era of "incurable" gonorrhea could be close.

In a study released Tuesday in the Journal of the American Medical Association, a group of scientists led by Vanessa Allen of Public Health Ontario, found that 6.7 percent of patients with gonorrhea at a Toronto clinic still had the disease after a round of cephalosporins, the last effective oral antibiotic used to treat the disease. Of 133 patients who returned for a "test of cure" visit, nine remained gonorrhea-positive. This is the first time cephalosporin-resistant gonorrhea has been found in humans in North America.

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My Comment: This is the nightmare scenario.

Will Diseases Soon Become 'Impossible To Treat'?

Experts Fear Diseases 'Impossible To Treat' -- The Independent

Alarming rise in bacteria resistant to antibiotics, Government report finds.

Britain is facing a "massive" rise in antibiotic-resistant blood poisoning caused by the bacterium E.coli – bringing closer the spectre of diseases that are impossible to treat.

Experts say the growth of antibiotic resistance now poses as great a threat to global health as the emergence of new diseases such as Aids and pandemic flu.

Professor Peter Hawkey, a clinical microbiologist and chair of the Government's antibiotic-resistance working group, said that antibiotic resistance had become medicine's equivalent of climate change.

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Are You Ready For A World Without Antibiotics?

Streptococcus pyrogens bacteria. Photograph: S Lowry/University of Ulster/Getty Images.

From The Guardian:

Antibiotics are a bedrock of modern medicine. But in the very near future, we're going to have to learn to live without them once again. And it's going to get nasty.

Just 65 years ago, David Livermore's paternal grandmother died following an operation to remove her appendix. It didn't go well, but it was not the surgery that killed her. She succumbed to a series of infections that the pre-penicillin world had no drugs to treat. Welcome to the future.

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World Faces Global Pandemic Of Antibiotic Resistance, Experts Warn

All antibiotic use "uses up" some of the effectiveness of that antibiotic, diminishing the ability to use it in the future, experts warn, and antibiotics can no longer be considered as a renewable source. (Credit: iStockphoto/David Marchal)

From Science Daily:

ScienceDaily (Sep. 18, 2008) — Vital components of modern medicine such as major surgery, organ transplantation, and cancer chemotherapy will be threatened if antibiotic resistance is not tackled urgently, warn experts on bmj.com.

A concerted global response is needed to address rising rates of bacterial resistance caused by the use and abuse of antibiotics or "we will return to the pre-antibiotic era", write Professor Otto Cars and colleagues in an editorial.

All antibiotic use "uses up" some of the effectiveness of that antibiotic, diminishing the ability to use it in the future, write the authors, and antibiotics can no longer be considered as a renewable source.

They point out that existing antibiotics are losing their effect at an alarming pace, while the development of new antibiotics is declining. More than a dozen new classes of antibiotics were developed between 1930 and 1970, but only two new classes have been developed since then.

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Antibiotic-Resistant Bacteria Spreading

From Future Pundit:

erome Groopman has a good article in The New Yorker surveying the growing threat of antibiotic-resistant bacteria.

Of the so-called superbugs—those bacteria that have developed immunity to a wide number of antibiotics—the methicillin-resistant Staphylococcus aureus, or MRSA, is the most well known. Dr. Robert Moellering, a professor at Harvard Medical School, a past president of the Infectious Diseases Society of America, and a leading expert on antibiotic resistance, pointed out that MRSA, like Klebsiella, originally occurred in I.C.U.s, especially among patients who had undergone major surgery. “Until about ten years ago,” Moellering told me, “virtually all cases of MRSA were either in hospitals or nursing homes. In the hospital setting, they cause wound infections after surgery, pneumonias, and bloodstream infections from indwelling catheters. But they can cause a variety of other infections, all the way to bacterial meningitis.” The first deaths from MRSA in community settings, reported at the end of the nineteen-nineties, were among children in North Dakota and Minnesota. “And then it started showing up in men who have sex with men,” Moellering said. “Soon, it began to be spread in prisons among the prisoners. Now we see it in a whole bunch of other populations.” An outbreak among the St. Louis Rams football team, passed on through shared equipment, particularly affected the team’s linemen; artificial turf, which causes skin abrasions that are prone to infection, exacerbated the problem. Other outbreaks were reported among insular religious groups in rural New York; Hurricane Katrina evacuees; and illegal tattoo recipients. “And now it’s basically everybody,” Moellering said. The deadly toxin produced by the strain of MRSA found in U.S. communities, Panton-Valentine leukocidin, is thought to destroy the membranes of white blood cells, damaging the body’s primary defense against the microbe. In 2006, the Centers for Disease Control and Prevention recorded some nineteen thousand deaths and a hundred and five thousand infections from MRSA.

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