The enzyme WWP-1, shown in green, is a key player in the signaling cascade that links dietary restriction to longevity in roundworms. Sensory neurons are shown in red. (Credit: Courtesy of Dr. Andrea C. Carrano, Salk Institute for Biological Studies)From Science Daily:
ScienceDaily (June 28, 2009) — Experiment after experiment confirms that a diet on the brink of starvation expands lifespan in mice and many other species. But the molecular mechanism that links nutrition and survival is still poorly understood. Now, researchers at the Salk Institute for Biological Studies have identified a pivotal role for two enzymes that work together to determine the health benefits of diet restriction.
When lacking one enzyme or the other, roundworms kept on a severely calorie-restricted diet no longer live past their normal lifespan, they report in the June 24, 2009, advance online edition of the journal Nature.
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