From Live Science:
A study of nasty and nice lab rats has scientists on the verge of knowing the genes that separate wild animals like lions and wolves from their tame cousins, cats and dogs.
Unlike their wild ancestors, house pets and other domesticated animals share the trait of tameness, meaning they tolerate or even seek out human presence. New research, which is published in the June issue of the journal Genetics and involved the interbreeding of friendly and aggressive rats, reveals gene regions that influence the opposing behaviors.
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