Sleep: Spring Cleaning For The Brain?

On the left, the brain of the well-rested blue fly has low levels of a synaptic protein called BRP in this 3D view from a confocal mircoscope. On the right, the brain of the sleep-deprived fly glows orange in areas of BRP concentration. (Bruchpilot or BRP is a protein involved in communication between neurons.)In the tired fly, the protein is present at high concentartions in three major areas of the fly's brain that are associated with learning. Sleep reduces the levels of this protein, an indication that synapses get smaller and/or weaker. This process of "downscaling" may be important so the brain is reset to normal levels of synaptic activity and can begin learning again the next day. (Credit: Courtesy of UW Health Public Affairs)

From Science Daily:

ScienceDaily (Apr. 11, 2009) — If you've ever been sleep-deprived, you know the feeling that your brain is full of wool.

Now, a study published in the April 3 edition of the journal Science has molecular and structural evidence of that woolly feeling — proteins that build up in the brains of sleep-deprived fruit flies and drop to lower levels in the brains of the well-rested. The proteins are located in the synapses, those specialized parts of neurons that allow brain cells to communicate with other neurons.

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