Genetic Reasons For Baldness

Hope for the hairless: Researchers in Europe isolated stem cells from the hair follicles of mice (shown here under a microscope) and transplanted them onto the backs of hairless animals, which then sprouted hair. Credit: Nature Genetics

Baldness Genes -- Technology Review

Finding the genetic causes could lead to new therapies for baldness.

It may be small comfort to anyone sporting a comb-over, but researchers have found a second genetic risk factor for baldness.

Two groups, working independently, found variants on chromosome 20 that are associated with male pattern baldness--the most common cause of hair loss in men, and the root of a multimillion-dollar industry devoted to protecting, nurturing, and transplanting hair.

A third report identifies a new kind of stem cell in the hair follicles of mice that, when transplanted onto the skin of hairless rodents, causes the animals to sprout tufts of hair.

These latest findings offer greater insight into the genetic underpinnings of male pattern baldness, and into the process that produces a glorious head of hair in the unafflicted. According to a research team led by Tim Spector of King's College London, figuring out the genetic variants linked to the disorder could lead to gene therapies for baldness. The discovery of a risk factor on chromosome 20 may point to "an intriguing new potential target" for gene therapy.

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