First Complete Cancer Genome Sequenced

These acute myeloid leukemia cells are from the bone marrow of the female patient whose complete genome was sequenced in the first decoding of a complete cancer genome. The genetic study implicated eight genes not previously associated with this form of cancer. Timothy Ley

From Science News:

Scientists decipher each of the 3 billion DNA bases from the genome of an acute myeloid leukemia tumor

For the first time, a complete cancer genome, and incidentally a complete female genome, has been decoded, scientists report online Nov. 5 in Nature. In a study made possible by faster, cheaper and more sensitive methods for sequencing DNA, the researchers pinpoint eight new genes that may cause a cell to turn cancerous.

“Since cancer is a disease of the genome, this newfound ability to determine the complete DNA sequence of a cancer cell is enormously powerful,” comments Francis Collins, a geneticist and former director of the National Human Genome Research Institute in Bethesda, Md., a group that raced to sequence the first entire human genome.

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Has Biodefense Spending Made Us Safer

Postal Anthrax Aftermath: Has Biodefense Spending Made Us Safer? -- Scientific American

The Anthrax attacks in 2001 led to a massive increase in biodefense funding, which critics claim has done more harm than good.

As the Federal Bureau of Investigation was about to move in, U.S. Army biodefense scientist Bruce Ivins committed suicide, thus possibly closing the chapter on the first—and so far only—fatal bioattack in U.S. history. The FBI alleges that Ivins, who worked at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) in Fort Detrick, Md., mailed anthrax-laden letters in September and October 2001 that killed five people. The incidents sparked a massive infusion of research funds to counter civilian bioterrorism, $41 billion spread over seven federal departments and agencies. Yet some observers argue that those funds have done little to guard against another bioterror incident, especially if the FBI is right about Ivins.

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The Historic Beginnings Of The Space Arms Race Part Two

From Space War:

he Soviet government was set to adopt the Polyot-Kosmos anti-satellite -- ASAT -- weapons system after Kosmos-252 successfully destroyed the first spacecraft in orbit on Nov. 1, 1968, and after successful subsequent launches.

However, in 1972 the Soviet Union and the United States signed the Strategic Arms Limitation Treaty -- SALT-I -- and the Anti-Ballistic Missile -- ABM -- Treaty, which also covered ASAT systems.

Depending on the pace of bilateral talks, the ASAT test program was either mothballed or resumed. The ASAT system was eventually adopted and subsequently upgraded.

In 1976 the Soviet Union began to launch second-generation satellite interceptors, featuring new target-acquisition and homing systems, first installed aboard Kosmos-814. Flying along a lower orbit, the latter quickly overtook the target satellite, accelerated and found itself less than 1,000 meters from the "victim."

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Physics The Next President Needs To Know

From Wired:

Physics may be the furthest thing from the minds of the presidential candidates right now, but a solid grasp of the science behind some of the latest headlines will be critical for the winner.

Physics has a history of intersecting with politics in ways both large and small, from the creation of the atomic bomb to nuclear meltdowns to terrorist methods. And now, with more specialized, high-tech issues to tackle than ever before, it is increasingly important that world leaders have an understanding of the underlying scientific concepts.

But that’s not necessarily the case, says UC Berkeley physicist Richard Muller, author of the book Physics for Future Presidents. For example, he argues that some terrorist threats, like dirty bombs, are overrated, while others, the low-tech stuff like natural gas bombs, receive little attention.

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Ancient Cave Yields Clues to Chinese History

From Live Science:

WASHINGTON (AP) — A stalagmite rising from the floor of a cave in China is providing clues to the end of several dynasties in Chinese history.

Slowly built from the minerals in dripping water over 1,810 years, chemicals in the stone tell a tale of strong and weak cycles of the monsoon, the life-giving rains that water crops to feed millions of people.

Dry periods coincided with the demise of the Tang, Yuan and Ming dynasties, researchers report in Friday's edition of the journal Science.

In addition, the team led by Pingzhong Zhang of Lanzhou University in China noted a change in the cycles around 1960 which they said may indicate that greenhouse gases released by human activities have become the dominant influence on the monsoon.

The Wanxiang Cave is in Gansu Province, a region where 80 percent of the rainfall occurs between May and September.

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Products (And Toys) From The Future

The link to the video is HERE.

How Anesthesia Knocks You Out

From Live Science:

During surgery, anesthesia immobilizes a person while putting them in a sleep-like state where there is no awareness and no pain.

But after more than a century of "going under," we still do not fully understand how anesthesia works, said Anthony Hudetz in the Department of Anesthesiology at the Medical College of Wisconsin, Milwaukee.

New research by Hudetz and his colleagues now suggests that anesthesia somehow disrupts information connections in the mind and perhaps inactivates two regions at the back of the brain.

Here's how it works: Think of each bit of information coming into the brain as the side of a die. Then, the first step in consciousness would be to identify which number or state turns up once you throw the die. But you can't identify that number without access to the other faces of the die. That's because every experience, every perception (or number in this example) is connected to all the others. When the faces of the die somehow become disconnected, a person would fall unconscious.

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Giant Simulation Could Solve Mystery Of 'Dark Matter'

A map of the dark matter in six halos similar to that of the Milky Way. The brighter colours correspond to regions of higher density and indicate where most of the gamma rays are expected to be produced. (Credit: Image courtesy of Durham University)

From Science Daily:

ScienceDaily (Nov. 6, 2008) — The search for a mysterious substance which makes up most of the Universe could soon be at an end, according to new research.

Dark matter is believed to account for 85 per cent of the Universe's mass but has remained invisible to telescopes since scientists inferred its existence from its gravitational effects more than 75 years ago.

Now the international Virgo Consortium, a team of scientists including cosmologists at Durham University, has used a massive computer simulation showing the evolution of a galaxy like the Milky Way to "see" gamma-rays given off by dark matter.

They say their findings, published in the prestigious scientific journal Nature (Thursday, November 6), could help NASA's Fermi Telescope in its search for the dark matter and open a new chapter in our understanding of the Universe.

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Energy Agency Warns Of 6°C Rise In Temperatures

From New Scientist Environment:

Our voracious appetite for energy is potentially putting the planet on the path for a 6°C rise in temperatures – which is far more than what climate specialists say the environment can cope with.

In its 2008 World Energy Outlook, the International Energy Agency says the 2009 Copenhagen climate summit will have to set ambitious carbon-limiting caps and that the energy sector must play a key role in making this possible.

European policy-makers have set themselves the goal of keeping temperature rises below 2°C relative to what they were before the industrial revolution. Last year, the Intergovernmental Panel on Climate Change issued its forecasts of how rises between 1°C and 5°C would change the environment (see table in Climate hange is here now, says major report). A rise of 6°C was off the charts.

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How Disease Can Wipe Out An Entire Species

Photo by Patricia Wynne
This illustration shows the rat species Rattus nativitatis, which went extinct on Australia's Christmas Island by 1908. In a new study of museum DNA samples, researchers report that the likely cause of the animals' extinction was an introduced disease.

From The MSNBC:

Rat study presents first evidence for extinction due to ‘hyperdisease’.

Disease can wipe out an entire species, reveals a new study on rats native to Australia's Christmas Island that fell prey to "hyperdisease conditions" caused by a pathogen that led to the rodents' extinction.

The study, published in the latest issue of the journal PLoS One, presents the first evidence for extinction of an animal entirely because of disease.

The researchers say it's possible for any animal species, including humans, to die out in a similar fashion, although a complete eradication of Homo sapiens would be unlikely.

"I can certainly imagine local population or even citywide 'extinction,' or population crashes due to introduced pathogens under a condition where you have a pathogen that can spread like the flu and has the pathogenicity of the 1918 flu or Ebola viruses," co-author Alex Greenwood, assistant professor of biological sciences at Old Dominion University in Norfolk, Va., told Discovery News.

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Fountain of Youth: Drug Restores Muscles

From Live Science:

A daily dose of an investigational medication has been found to restore muscle mass in the arms and legs of older adults and improve some of their biochemistry to levels found in healthy young adults, suggesting an anti-frailty drug has been found.

The drug, called MK-677, was evaluated for its safety and effectiveness in a study that showed the drug restored 20 percent of muscle mass loss associated with normal aging. In fact, levels of growth hormone (GH) and of insulin-like growth factor I (IGF- I) in healthy seniors who took the drug increased to the levels found in healthy young adults, said Michael O. Thorner, a professor of internal medicine and neurosurgery at the University of Virginia Health System.

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Gobekli Tepe: The World’s First Temple?

From The Smithsonian:

Predating Stonehenge by 6,000 years, Turkey's stunning Gobekli Tepe upends the conventional view of the rise of civilization.

Six miles from Urfa, an ancient city in southeastern Turkey, Klaus Schmidt has made one of the most startling archaeological discoveries of our time: massive carved stones about 11,000 years old, crafted and arranged by prehistoric people who had not yet developed metal tools or even pottery. The megaliths predate Stonehenge by some 6,000 years. The place is called Gobekli Tepe, and Schmidt, a German archaeologist who has been working here more than a decade, is convinced it's the site of the world's oldest temple.

"Guten Morgen," he says at 5:20 a.m. when his van picks me up at my hotel in Urfa. Thirty minutes later, the van reaches the foot of a grassy hill and parks next to strands of barbed wire. We follow a knot of workmen up the hill to rectangular pits shaded by a corrugated steel roof—the main excavation site. In the pits, standing stones, or pillars, are arranged in circles. Beyond, on the hillside, are four other rings of partially excavated pillars. Each ring has a roughly similar layout: in the center are two large stone T-shaped pillars encircled by slightly smaller stones facing inward. The tallest pillars tower 16 feet and, Schmidt says, weigh between seven and ten tons. As we walk among them, I see that some are blank, while others are elaborately carved: foxes, lions, scorpions and vultures abound, twisting and crawling on the pillars' broad sides.

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Want a Free Education? A Guide to Free Online Video Lectures

U Tube -- Boston.com

Want a free education? A brief guide to the burgeoning world of online video lectures.

RESERVE ANOTHER LAUREL for Edward O. Wilson, the Pellegrino University Professor emeritus at Harvard, serial Pulitzer winner, and prominent intellectual: online celebrity.

Forget Charlie Rose - Wilson has Google for a soapbox. Amid the amateur-hour piffle of YouTube "talent" and skateboarding dogs, the famed botanist stands in bold relief, with more than 500 Google video search results to his credit: Interviews ranging far afield of TV shows to a spate of appearances on several Web-only video platforms such as Meaningoflife.tv, Bigthink.com, Fora.tv, and the online home of the Technology Entertainment Design (TED) conference.

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Has New Physics Been Found At The Ageing Tevatron?

The Collider Detector at Fermilab has found hints of new physics
(Image: Fermilab)

From The New Scientist Space:

While engineers at the Large Hadron Collider (LHC) race to fix its teething problems and start looking for new particles, its ageing predecessor is refusing go silently into the night.

Last week, physicists announced that the Tevatron particle accelerator at Fermilab in Batavia, Illinois, has produced particles that they are unable to explain. Could it be a sign of new physics?

The Collider Detector at Fermilab (CDF) monitors the particles that spew from collisions between protons and anti-protons, which are accelerated and smashed head-on by the Tevatron. The collision occurs inside the 1.5-centimetre-wide "beam pipe" that confines the protons and anti-protons, and the particles created are tracked by surrounding layers of electronics.

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World’s Largest Concentrated Solar Project in Spain

From Clean Technica:

Earlier today, concentrated solar company SolFocus announced that it has signed a deal to install over 10 MW of its systems in Spain for EMPE Solar. Upon its completion in 2010, the $103 million, multi-site project will be the largest concentrated solar deployment in the world. SolFocus estimates that the project will be able to meet the domestic energy requirements of 40,000 homes.

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Japanese Clone Mouse From Frozen Cell, Aim For Mammoths

This handout picture, released by Japan natural science research center shows a cloned mouse (left) created with a new technology by using a frozen dead cell of a mouse. (AFP/Teruhiko Wakayama)

From Breitbart/AFP:

Japanese scientists said Tuesday they had created a mouse from a dead cell frozen for 16 years, taking a step in the long impossible dream of bringing back extinct animals such as mammoths.

Scientists at the government-backed research institute Riken used the dead cell of a mouse that had been preserved at minus 20 degrees Celsius (minus 4 degrees Fahrenheit) -- a temperature similar to frozen ground.

The scientists hope that the first-of-a-kind research will pave the way to restore extinct animals such as the mammoth.

The findings were published in the Proceedings of the National Academy of Sciences in the United States.

The scientists extracted a cell nucleus from an organ of the dead mouse and planted it into an egg of another mouse which was alive, leading to the birth of the cloned mouse, the researchers said.

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Massive Waves A Mystery At Maine Harbor

Owen Johnson (left) and his father, Peter, repaired damage yesterday done by waves in Boothbay Harbor. (Joel Page for The Boston Globe)

From Boston.com:

Dockworker Marcy Ingall saw a giant wave in the distance last Tuesday afternoon and stopped in her tracks. It was an hour before low tide in Maine's Boothbay Harbor, yet without warning, the muddy harbor floor suddenly filled with rushing, swirling water.

In 15 minutes, the water rose 12 feet, then receded. And then it happened again. It occurred three times, she said, each time ripping apart docks and splitting wooden pilings.

"It was bizarre," said Ingall, a lifelong resident of the area. "Everybody was like, 'Oh my God, is this the end?' " It was not the apocalypse, but it was a rare phenomenon, one that has baffled researchers. The National Weather Service said ocean levels rapidly rose in Boothbay, Southport, and Bristol in a matter of minutes around 3 p.m. on Oct. 28 to the surprise of ocean watchers. Exactly what caused the rogue waves remains unknown.

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James Bond Gadgets

Photos: Top 15 James Bond Gadgets
-- Computer Weekly

There is a definite bond between secret agents and gadgets. From the Geiger counter in Dr No, James Bond has been bedecked with hardware that has ranged from the plausible to the fantastical. The current Bond (Daniel Craig, starring in The Quantum of Solace) is a relative technophobe, which is a pity because the Bond devices have always stirred the imagination. Here are our top fifteen gadgets that are either real or have perhaps inspired technological innovation.

What do you think? E-mail us your favourite Bond gadget or even let us know if we've missed any. Send your comments to computerweekly.com with 'Bond gadgets' in the headline.

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How Geoengineering Works: 5 Big Plans to Stop Global Warming

(Photograph by Tarko Sudiarno/AFP/Getty Images)

From Popular Science:

At first blush, geoengineering sounds like outrageous junk science. Surely there's an easier solution to the problem of global warming than technologically altering Earth's atmosphere, its cloud formations and even outer space. But when compared with the alternative—drastically reducing the amount of carbon dioxide blanketing the planet by changing the behavior of billions of people and thousands of industries, not to mention slow-moving governments—some scientists are beginning to take the seemingly outrageous schemes a lot more seriously. Here are the mechanics behind five plans to jury-rig the Earth.

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The First Few Minutes After Death

EEG During Cardiac Arrest (Image From Popsci)

From Popsci:

A three-year study will explore the nature of death and consciousness

After countless accounts of near-death experiences, dating as far back as ancient Greece, science is now taking serious steps forward to explore the nature of the phenomenon. A new project aims to determine whether the experience is a physiological event or evidence that the human consciousness is far more complicated than we ever believed.

The Human Consciousness Project sets out to explore the nature of human consciousness and the brain. The first step of the project is the "Awareness During Resuscitation" study, a collaboration among more than 25 medical centers throughout the United States, Canada, and Europe.

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