New Type of Genetic Variation Could Strengthen Natural Selection

Scanning electrograph image of Saccharomyces cerevisiae. (Credit: Image courtesy of NASA)

From Science Daily:

Science Daily (Feb. 18, 2010) — The unexpected discovery of a new type of genetic variation suggests that natural selection -- the force that drives evolution -- is both more powerful and more complex than scientists have thought.

"We have discovered that natural selection can act not only on whole organisms and individual genes, but also on gene networks," says Antonis Rokas, assistant professor of biological sciences at Vanderbilt University and senior author of the paper reporting the discovery that was published in the February 18 issue of the journal Nature.

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Genes Reveal 'Biological Ageing'

Photo: Telomeres at the end of chromosomes shorten with age.

From The BBC:

Gene variants that might show how fast people's bodies are actually ageing have been pinpointed by scientists.

Researchers from the University of Leicester and Kings College London say the finding could help spot people at higher risk of age-related illnesses.

People carrying the variant had differences in the "biological clock" within all their cells.

The British Heart Foundation said the findings could offer a clue to ways of preventing heart disease.

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Genes Help Explain Who Gets Fit

From Live Science:

When you put in hours at the gym, you expect to get fitter. It turns out, that assumption doesn't hold true for everyone. A new study suggests specific genes may determine, at least in part, how much we really benefit from exercise.

While "benefit from exercise" can mean plenty of things, from slimming down to boosting one's ability to complete a marathon, the researchers specifically looked at what is called VO2 max, or aerobic capacity. This is a measure of how much blood your heart pumps and how much oxygen your muscles consume when they constrict to, say, move your legs on a treadmill.

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Genetic Test For 'Speed Gene' In Thoroughbred Horses

New research identifies the 'speed gene' contributing to a specific athletic trait in thoroughbred horses. (Credit: iStockphoto/Derek Dammann)

From Science Daily:

Science Daily (Feb. 3, 2010) — Groundbreaking research led by Dr Emmeline Hill, a leading horse genomics researcher at University College Dublin's (UCD) School of Agriculture, Food Science and Veterinary Medicine has resulted in the identification of the 'speed gene' in thoroughbred horses.

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Why The Y Chromosome Is A Hotbed For Evolution

From Times Online:

The Y chromosome is often seen as the rotten corner of the human genome — a place of evolutionary decline that is slowly decaying and threatening the end of man. Reports of its imminent demise, however, have been exaggerated.

Research has indicated that, far from stagnating, the male chromosome is a hotspot of evolution that is changing more quickly than any other part of humanity’s genetic code.

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Male Chromosome Evolving Fastest, Study Shows

A scanning probe microscope image of human chromosomes.

From The Telegraph:

The Y chromosome is evolving far faster than the rest of the human genetic code, according to a study by scientists in America.

The research compared the Y chromosomes - which determine a man’s sex - from humans and chimpanzees, man’s nearest living relatives, and showed that they are about 30 per cent different.

That is far greater than the two per cent difference between the rest of the human genetic code and that of the chimpanzee’s. The changes occurred in the last six million years or so, relatively recently when it comes to evolution.

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Gene Rice On Its Way In China

GM crops have been cleared for commercial cultivation (Image: Jeff Hutchens/Getty)

From New Scientist:

Genetically modified rice cleared for commercial sale could be growing on Chinese farms as early as next year, making China the first country to allow commercial cultivation of GM strains. The field trials required for any new variety are now under way, following official safety clearance November.

Two varieties, called Huahui 1 and Bt Shanyou 63, received clearance and should be launched within the next two years. Both contain "Bt" proteins from the Bacillus thuringiensis bacterium to protect them against the rice stem borer, the most serious rice pest in China.

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The Decade We Learned The Language Of Life

From The Guardian:

How the mapping of the 3bn letters of the human genome sparked a new age of biology that is only just beginning.

It was the decade that launched a new age of science, and it came as no surprise. Researchers had foreseen the rise of biology in the 1990s and expected nothing less than a transformation of modern medicine and giant leaps in our knowledge of life on Earth.

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2010 Preview: Genome Sequencing For All

Illuminating the "dark matter" of the genome
(Image: Roz Woodward/Stone/Getty)

From New Scientist:

Fancy having your genome sequenced? It's becoming affordable, and 2010 will see the launch of a wave of genetic discovery that could turn it into a purchase worth making.

In the coming months, plummeting costs will allow gene hunters to start routinely working with complete human genome sequences. These should start to illuminate the "dark matter" of the genome - the as yet unknown genetic influences on our health that are missed by current scans.

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World's Oldest Known DNA Discovered

DNA from 419-million-year-old bacteria may have belonged to the descendants of
the world's first life forms (Source: iStockphoto)

From ABC News (Australia):

It won't make Jurassic Park a reality, but scientists have discovered 419 million-year-old DNA intact inside ancient salt deposits.

The genetic material, the oldest ever found, belongs to salt-loving bacteria whose ancestors may have been among the first life forms on Earth.

Scientists have previously recovered similar genetic material from the Michigan Basin, the same region where the latest discovery was made. But the DNA was so similar to that of modern microbes that many scientists believed the samples had been contaminated.

Not so this time around.

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15 Cigarettes: All It Takes To Harm Genes

Scientists believe this new insight into the genetics of cancer will eventually lead to new drugs that target the specific changes to the gene that helps to trigger the disease. ALAMY

From The Independent:

Study reveals the genetic mutations suffered by smokers who go on to develop lung cancer.

One genetic mutation occurs on average for every 15 cigarettes that a typical lung-cancer patient smokes, according to a study that has identified for the first time all of the mutations acquired during the lifetime of a cancer patient.

Scientists have completed a full genetic analysis of the genomes of cancer patients, and hope the information will lead to a fundamental understanding of the causes of cancer – and possibly drugs and treatments – by identifying the mutations that turn a healthy cell into a cancerous tumour cell.

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Genetic 'Map' Of Asia's Diversity

The study indicates that all of Asia was populated through one migration event.

From The BBC:

An international scientific effort has revealed the genetics behind Asia's diversity.

The Human Genome Organisation's (HUGO) Pan-Asian SNP Consortium carried out a study of almost 2,000 people across the continent.

Their findings support the hypothesis that Asia was populated primarily through a single migration event from the south.

The researchers described their findings in the journal Science.

They found genetic similarities between populations throughout Asia and an increase in genetic diversity from northern to southern latitudes.

The team screened genetic samples from 73 Asian populations for more than 50,000 single-nucleotide polymorphisms (SNPs).

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From Minnie To Mickey (And All They Did Was Turn Off A Gene)

The cells of the female ovary were transformed into cells normally found in male testes by turning off a gene during the development of the mouse embryo. Alamy

From The Independent:

Simple technique changes sex of a mouse – and reveals the gender war that rages in all of us.

The battle of the sexes is a never-ending war waged within ourselves as male and female elements of our own bodies continually fight each other for supremacy. This is the astonishing implication of a pioneering study showing that it is possible to flick a genetic switch that turns female ovary cells into male testicular tissue.

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Human Genetic Revelations Coming In 2010

From Future Pundit:

Writing in The Economist Geoffrey Miller says in 2010 human genetic research results will show some politically incorrect beliefs about human nature are correct. Looking ahead to 2010 and beyond I am reminded of Dr. Elisabeth Kubler-Ross's 5 stages of death. I think these apply to beliefs as well.

Human geneticists have reached a private crisis of conscience, and it will become public knowledge in 2010. The crisis has depressing health implications and alarming political ones. In a nutshell: the new genetics will reveal much less than hoped about how to cure disease, and much more than feared about human evolution and inequality, including genetic differences between classes, ethnicities and races.

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Genetics Rather Than Stress To Blame For Grey Hair

From The Telegraph:

Women who find themselves going grey should blame their parents rather than their stressful lifestyles, research has found.

Scientists studied more than 200 identical and non-identical twins between the ages of 59 and 81. They found that there was little difference between the greyness of identical twin sisters, implying that their varying lifestyles or upbringing had little impact.

Among non-identical siblings that did have differing levels of grey hair, 90 per cent of cases could be attributed to differing genetic factors, researchers from Unilever, who conducted the research published it in US journal PLoS ONE, found.

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First 'Genetic Map' of Han Chinese May Aid Search for Disease Susceptibility Genes

DNA on abstract background. Researchers have published the first genetic historical map of the Han Chinese, the largest ethnic population in the world, as they migrated from south to north over evolutionary time. (Credit: iStockphoto/Andrey Prokhorov)

From Science Daily:

Science Daily (Nov. 26, 2009) — The first genetic historical map of the Han Chinese, the largest ethnic population in the world, as they migrated from south to north over evolutionary time, was published online November 25 in the American Journal of Human Genetics by scientists at the Genome Institute of Singapore (GIS).

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Enhancing Access to Genomic Medicine

Credit: Technology Review

From Technology Review:

A startup aims to calculate the value in the onslaught of genetic tests.

Per Lofberg wants to bring genomic medicine to the masses by overcoming one of the field's biggest barriers--getting insurers and other payers to cover the growing numbers of genetic tests reaching the market. To achieve that, he founded Generation Health, a health benefit management company that aims to sift through the data on these tests, which range from those that predict an individual's risk of heart disease or cancer to those that determine how well a patient metabolizes a certain drug. Lofberg's goal is to find the ones that provide the greatest medical utility and economic value.

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Decoded Corn Genome Promises Higher Yields, Better Biofuels, New Plastics

Corn, Illinois: Randy Wick/Flickr

From Popular Science:

With its annual output of over 330 million tons a year feeding animals, running cars, and decorating South Dakota tourist attractions, maize is clearly Americas most important crop. That's why the newly published complete corn genome could drastically change the food, automotive and plastic industries. Already, scientists have identified genes that could boost yield, change the cell wall to make more biofuel, or raise the nutritional value of this vital cereal.

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Plant Experts Unveil DNA Barcode

Photo: Identifying a plant's DNA "barcode" will help tell is if it is being illegally traded

From The BBC:

Hundreds of experts from 50 nations are set to agree on a "DNA barcode" system that gives every plant on Earth a unique genetic fingerprint.

The technology will be used in a number of ways, including identifying the illegal trade in endangered species.

The data will be stored on a global database that will be available to scientists around the world.

The agreement will be signed at the third International Barcode of Life conference in Mexico City on Tuesday.

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Early Life Stress 'Changes' Genes

Photo: Mice that are abandoned as pups have behavioural problems later on

From BBC News:

A study in mice has hinted at the impact that early life trauma and stress can have on genes, and how they can result in behavioural problems.

Scientists described the long-term effects of stress on baby mice in the journal Nature Neuroscience.

Stressed mice produced hormones that "changed" their genes, affecting their behaviour throughout their lives.

This work could provide clues to how stress and trauma in early life can lead to later problems.

The study was led by Christopher Murgatroyd, a scientist from the Max Planck Institute of Psychiatry in Munich, Germany.

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