From Science Daily:ScienceDaily (Feb. 14, 2009) — An estimated 15% of cancer cases can be linked to a viral infection, however the biological changes that cause some asymptomatic carriers of a virus to develop full-blown tumors are not well understood. In a study published online in Genome Research, scientists have mapped a chemical modification of DNA in three oncogenic viruses (Epstein-Barr, human papilloma virus, and hepatitis B virus) and found that the viral genome undergoes critical changes during the progression of disease, with implications for the development of new methods of prevention, diagnosis, and treatment.
Worldwide, most people are already infected with the Epstein-Barr virus, and millions are infected with the human papilloma virus and the hepatitis B virus. Many of these individuals will develop disease, and some will eventually develop a viral-related cancer such as lymphoma, liver cancer, or cervical cancer. Understanding how infections of viruses such as these can progress to cancer in some individuals is essential to the development of new methods to attack the virus and prevent malignancies.
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