A 3-D image of brain atrophy differences in mild cognitive impairment (MCI) patients and mild Alzheimer's disease patients. Alzheimer's patients show far more damage overall, especially in cortical areas of the brain. Credit: Dr. Liana G. Apostolova, David Geffen School of Medicine at UCLAFrom Live Science:
A slow starvation of the brain over time is one of the major triggers of the biochemistry that causes some forms of Alzheimer's, according to a new study that is helping to crack the mystery of the disease's origins.
An estimated 10 million baby boomers will develop Alzheimer's in their lifetime, according to the Alzheimer's Association. The disease usually begins after age 60, and risk rises with age. The direct and indirect cost of Alzheimer's and other dementias is about $148 billion a year.
Robert Vassar of Northwestern University, the study's lead author, found that when the brain doesn't get enough of the simple sugar called glucose — as might occur when cardiovascular disease restricts blood flow in arteries to the brain — a process is launched that ultimately produces the sticky clumps of protein that appear to be a cause of Alzheimer's.
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