The dots in the picture are immune cells called microglia (highlighted with a black stain), which are more prevalent in brains affected by Alzheimer’s. Photograph: Carol Colton lab, Duke Universit/PA
The Guardian: Alzheimer's treatment closer as brain inflammation shown to be key
Study shows inflammation-reducing chemical prevents memory and behavioural problems in diseased mice, raising hopes for human treatment
Scientists have fresh hopes for an Alzheimer’s treatment after experiments to reduce inflammation in diseased mouse brains prevented memory and behavioural problems in the animals.
Alzheimer’s disease has long been linked to disruption in the brain’s immune system, but the latest research adds to evidence that inflammation in the brain is not so much caused by the disease, but is a driver of the disorder.
Researchers at Southampton University studied tissues from healthy human brains and others affected by Alzheimer’s disease. They found that Alzheimer’s brains had more immune cells, known as microglia, than healthy brains.
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