Cooking Up Millions Of Viruses For A New Vaccine

Research assistants at New York Medical College on Tuesday prepared to harvest swine flu virus that had been grown in eggs. Béatrice de Géa for The New York Times

From The New York Times:

VALHALLA, N.Y. — As soon as Doris Bucher learned that a new strain of swine flu had turned up in the United States, she e-mailed the Centers for Disease Control and Prevention offering to send materials that might be useful in making a vaccine.

Her colleagues at the C.D.C. had a better idea. Less than a week later, they sent a sample of the new type of virus, influenza A(H1N1), to Dr. Bucher, an associate professor of microbiology and immunology at New York Medical College.

Dr. Bucher, a cheerful, fast-talking scientist who has been involved in flu research for 40 years, runs a laboratory here in Westchester County that is highly regarded for its skill at turning flu viruses into “seed stock” — a form of the virus that will grow rapidly in eggs so that drug companies can use it to make hundreds of millions of doses of vaccine.

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Culture May Be Encoded in DNA

From Wired Magazine:

Knowledge is passed down directly from generation to generation in the animal kingdom as parents teach their children the things they will need to survive. But a new study has found that, even when the chain is broken, nature sometimes finds a way.

Zebra finches, which normally learn their complex courtship songs from their fathers, spontaneously developed the same songs all on their own after only a few generations.

“We found that in this case, the culture was pretty much encoded in the genome,” said Partha Mitra of Cold Spring Harbor Laboratory in New York, co-author of a study in Nature on Sunday.

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Nanoneedle Is Small In Size, But Huge In Applications

Schematic illustrating the strategy of the nanoneedle-based delivery of bioprobes into the cell, along with the combined fluorescence and bright-field images showing the nanoneedle penetrating through the cell membrane, and the quantum dots (in red) target-delivered into the cytoplasm and the nucleus of a living cell. (Credit: Image courtesy of University of Illinois at Urbana-Champaign)

From Science Daily:

ScienceDaily (May 6, 2009) — Researchers at the University of Illinois have developed a membrane-penetrating nanoneedle for the targeted delivery of one or more molecules into the cytoplasm or the nucleus of living cells. In addition to ferrying tiny amounts of cargo, the nanoneedle can also be used as an electrochemical probe and as an optical biosensor.

"Nanoneedle-based delivery is a powerful new tool for studying biological processes and biophysical properties at the molecular level inside living cells," said

Min-Feng Yu, a professor of mechanical science and engineering and corresponding author of a paper accepted for publication in Nano Letters, and posted on the journal's Web site.

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Reality Check: The Science Of 'Star Trek'

From Live Science:

When "Star Trek" first promised to boldly go where no man had gone before, it spun tales involving a dazzling array of futuristic technologies such as phasers and cloaking devices. How many of those devices are now actually realities today, and how many remain in the distant future?

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Pandemics That Were And Weren’t

1956/1958- The Asian Flu: Far less deadly than the Spanish flu, the Asian flu of 1956-1958 killed about 70,000 Americans. The strain mutated from an earlier H2N2 flu that had originated in Russia and gone pandemic in 1889. With its relatively low death rate and long duration, the Asian Flu perfectly exemplifies how most pandemics don’t threaten the collapse of civilizations, but merely exacerbate the problems already caused by seasonal flu. A girl gargling broth in Sagamihara Hospital, Japan, during the 1957 flu outbreak, courtesy of the National Museum of Health and Medicine, via Flickr.com

From Popsci.com:

After a week of swine flu hysteria, PopSci.com takes a look back at the history of pandemic flu.

More often than not, it’s the newer diseases, like HIV or Ebola, that grab all the headlines. But those Johnny-come-lately microbes have nothing on one of the most dangerous, and most ancient, viruses that afflicts mankind: influenza.

Medicine has grappled with the deadly influenza virus since the time of Hypocrites, and some historians have identified flu epidemics as far back as ancient Rome. In a regular year, the Center for Disease Control and Prevention estimates that 36,000 Americans die from the seasonal flu, while the virus costs the nation between $71 and $160 billion. That’s ten times the death toll of 9/11 and double the cost of Hurricane Katrina, but it's far less noticeable, as the virus mainly kills the very old and very young, and the cost is spread out over the entire year in question.

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Virus Hunters: Inside Maryland's New Biosafety Level 4 Lab

Left: The air-lock entrance to the lab’s hot zone. Right: A biohazard suit protects Peter Jahrling, chief virus hunter at the Integrated Research Facility in Fort Detrick, Md.

From Popular Mechanics:

The swine flu has killed more than a hundred people in Mexico with reports of at least 40 infections in the United States. Could the flu cause a pandemic? Health researchers don't think so now, but the Center for Disease Control still suggests Americans take precautions by washing hands, covering coughs and staying home if taken ill. Behind closed doors, the NIH continues to study dangerous diseases of all varieties, preparing to stop the next outbreak before it begins. PM got an early inside look at American's newest infectious disease research laboratory, to see how scientists study the world's deadliest pathogens.

The integrated research facility at Fort Detrick, Md., doesn’t look menacing. The three-story glass-and-brick structure, which could fit seamlessly into any suburban office park, is typical of buildings designed by architects who read studies linking sunlight with worker productivity. The leather chairs in the atrium seem to encourage lounging. The National Institute of Allergy and Infectious Diseases, which operates the IRF, plans to install a coffee bar in the atrium.

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Solar Storms Ahead: Is Earth Prepared?

In this artist’s conception, a coronal mass ejection from the sun is mapped in 3-D by NASA’s pair of STEREO sun-observing satellites. (NASA)

From The Christian Science Monitor:

Sunspot cycle beginning in 2012 may put satellites, power grids at risk.

When we look at the sun (carefully), it appears to be a uniform, unchanging star. But scientists and engineers have a much different perspective. To them, the sun is a dynamic, chaotic, and poorly understood caldron of thermonuclear forces, one that can spit out fierce bursts of radiation at any time.

And when Earth lies in the path of that blast, the flare can play havoc with power grids, disrupt radio communications, and disturb or disable satellites. Fifty years into the Space Age, Earth has avoided the worst the sun can deliver – so far.

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New, Fast-Evolving Rabies Virus Found -- And Spreading

Foxes (such as this red fox photographed in 2008 in Wyoming) may be spreading rabies like humans spread the flu—through simple socialization—in northern Arizona, experts say. The rabies virus appears to have mutated surprisingly quickly and become virulent in foxes and skunks, experts said in April 2009. Photograph by Andy Carpenean/Laramie Boomerang via AP

From National Geographic:

Evolving faster than any other new rabies virus on record, a northern-Arizona rabies strain has mutated to become contagious among skunks and now foxes, experts believe.

The strain looks to be spreading fast, commanding attention from disease researchers across the United States.

It's not so unusual for rabid animals to attack people on hiking trails and in driveways, or even in a bar—as happened March 27, when an addled bobcat chased pool players around the billiards table at the Chaparral in Cottonwood.

Nor is it odd that rabid skunks and foxes are testing positive for a contagious rabies strain commonly associated with big brown bats.

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Birth Control For Men In One Injection

Photo: Getty Images

From The Independent:

Chinese scientists succeed with testosterone jab trial on 1,000 volunteers.

Scientists believe they are one step closer to developing an effective male contraceptive jab after successfully carrying out the largest feasibility study to date.

Researchers at the National Research for Family Planning in Beijing injected 1,000 healthy, fertile male patients with a testosterone-based jab over a two-year period and found only 1 per cent went on to father a child. The men were all aged between 20 and 45 and had fathered at least one child in the two years before the testing began. They were also all involved with healthy female partners between the ages of 18 and 38 who had no reproductive problems of their own.

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Bill Gates Pours Thousands Into Unconventional Health Research

The Bill & Melinda Gates Foundation has thrown a lifeline to scores of projects awarding 81 $100,000 (£65,000) grants Photo: BLOOMBERG NEWS

From The Telegraph:

They are projects that would normally struggle to find funding: creating an anti-viral tomato, a flu-resistant chicken and a magnet that can detect malaria.

But the Bill & Melinda Gates Foundation has thrown a lifeline to scores of projects like these, awarding 81 $100,000 (£65,000) grants in a bid to support innovative, unconventional global health research.

The five-year health research grants are designed to encourage scientists to pursue bold ideas that could lead to breakthroughs, focusing on ways to prevent and treat infectious diseases, such as HIV, malaria, tuberculosis, pneumonia and diarrheal diseases.

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My Comment: Its his money .... he can do what he wants.

Botnets Took Control Of 12 Million New IPs This Year

From Wired News:

Botnet criminals have taken control of almost 12 million new IP addresses since January, according to a quarterly report (.pdf) from anti-virus firm, McAfee. The United States has the largest number of botnet-controlled machines, with 18 percent of them based here.

The number of zombie machines represents a 50-percent rise over last year.

Researchers attribute the explosion to botnet controllers trying to recoup spamming abilities after authorities took down a hosting facility last year that catered to international firms and syndicates involved in spamming and botnet control.

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NASA's Fermi Explores High-energy 'Space Invaders'

The Large Area Telescope (LAT) on Fermi detects gamma-rays by tracking the electrons positrons they produce after striking layers of tungsten. This ability also makes the LAT an excellent tool for exploring high-energy cosmic rays. (Credit: NASA/Goddard Space Flight Center Conceptual Image Lab)

From Science Daily:

Since its launch last June, NASA's Fermi Gamma-ray Space Telescope has discovered a new class of pulsars, probed gamma-ray bursts and watched flaring jets in galaxies billions of light-years away. At the American Physical Society meeting in Denver, Colo., Fermi scientists revealed new details about high-energy particles implicated in a nearby cosmic mystery.

"Fermi's Large Area Telescope is a state-of-the-art gamma-ray detector, but it's also a terrific tool for investigating the high-energy electrons in cosmic rays," said Alexander Moiseev, who presented the findings. Moiseev is an astrophysicist at NASA's Goddard Space Flight Center in Greenbelt, Md.

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Oldest Surface On Earth Discovered

This natural "desert pavement" in Israel's Negev Desert has been dated to about 1.8 million years old, the olest known vast expanse of surface area on the planet. Credit: Ari Matmon, Hebrew University

From Live Science:

Earth's surface is mostly fresh in geologic terms.

Weathering — wind and water, freezing and thawing — takes its toll, and longer-term changes caused by volcanic activity and sliding crustal plates, known as tectonic activity, fold today's ground into tomorrow's interior.

The constant makeover of the planet is typically fastest in the mountains, slower in the tectonically inactive deserts.

A new study of ancient "desert pavement" in Israel's Negev Desert finds a vast region that's been sitting there exposed, pretty much as-is, for about 1.8 million years, according to Ari Matmon and colleagues at Hebrew University of Jerusalem.

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The First European: Created From Fragments Of Fossil, The Face Of Our Forbears 35,000 Years Ago

The first modern European: Forensic artist Richard Neave reconstructed the face based on skull fragments from 35,000 years ago

From Daily Mail:

Dressed in a suit, this person would not look out of place in a busy street in a modern city.

The clay sculpture, however, portrays the face of the earliest known modern European - a man or woman who hunted deer and gathered fruit and herbs in ancient forests more than 35,000 years ago.

It was created by Richard Neave, one of Britain's leading forensic scientists, using fossilised fragments of skull and jawbone found in a cave seven years ago.

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Sun Oddly Quiet -- Hints At Next "Little Ice Age"?

In July 2000 the sun was at a peak in activity, as seen by the speckling of sunspots spied by NASA's Solar and Heliospheric Observatory (SOHO) spacecraft. But the sun was a blank disk in March 2009, when it was the quietest it has been since the 1950s. The current sunspot deficit has caused some scientists to recall the Little Ice Age of the early 1600s and late 1700s, a prolonged, localized cold spell linked to a decline in solar activity. Images courtesy SOHO, the EIT Consortium, and the MDI Team

From National Geographic:

A prolonged lull in solar activity has astrophysicists glued to their telescopes waiting to see what the sun will do next—and how Earth's climate might respond.

The sun is the least active it's been in decades and the dimmest in a hundred years. The lull is causing some scientists to recall the Little Ice Age, an unusual cold spell in Europe and North America, which lasted from about 1300 to 1850.

The coldest period of the Little Ice Age, between 1645 and 1715, has been linked to a deep dip in solar storms known as the Maunder Minimum.

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Internet Struggles To Contain Carbon Footprint

Current Generation Google Servers (Photo from Perspectives)

From The Telegraph:

Internet companies are struggling to control their carbon footprint as the web consumes more energy and money.

With more than 1.5 billion people online around the round, scientists estimate the carbon footprint of the internet is growing by more than 10 per cent each year.

Many internet companies are struggling to manage the costs as energy bills soar, while their advertising revenues come under pressure from the recession.

It is thought one site facing problems is video website YouTube. Although now the world's third-biggest website, it requires a heavy subsidy from Google, its owner.

Recent analysis by Credit Suisse suggest it could lose as much as £317m this year.

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Poison Bacteria Set Up Worst Extinction

In the three to four million years before the Permian-Triassic extinction, illustrated here, the seas were already oxygen-starved, according to a new study. The stagnant depths were a haven for bacteria that belched poison that crippled life on Earth, leaving it vulnerable to the volcanic knockout punch that would soon come. Lunar and Planetary Institute

From MSNBC:

New finding gets to heart of a long debate among extinction researchers.

In the ancient oceans, stagnant depths harbored poison-belching bacteria that crippled life on Earth, leaving it vulnerable to a knockout punch from volcanic eruptions, according to a new study.

Three to four million years before the Permian-Triassic extinction, also known as the Great Dying, the seas were already becoming oxygen-starved and sour, said the study in the journal Earth and Planetary Science Letters.

Changqun Cao of the Chinese Academy of Sciences in Nanjing and a team of researchers studied rock samples drilled in central China from the late Permian and early Triassic periods. Rocks from the extinction itself date to 252.2 million years ago, and show several chemical signs of catastrophe.

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Unknown Internet 6: Where Are The Net's Dark Corners?

Photo: Some websites will leave your computer infected with viruses or worms, but the "black holes" are just as bad (Image: Image Source / Rex)

From New Scientist:

There are plenty of places online that you would do well to steer clear of. A brief visit to some unsavoury websites, for instance, could leave your computer infected with worms or viruses. Then there are the "black holes" to worry about.

If your emails mysteriously disappear, or your favourite website is suddenly unobtainable, you might have run into one. Though nowhere near as destructive as their cosmological cousins, information black holes can create all kinds of problems for surfers. Essentially they are points on the network at which data packets simply disappear due to broken connections, say, or misconfigured routers - devices that maintain lists of addresses and which help direct internet traffic. A team including computer scientist Ethan Katz-Bassett at the University of Washington in Seattle has detected almost 1.5 million black holes since it began looking in 2007. The majority persist for over 2 hours, he says. Unfortunately it is tough to predict where they will appear next, so it's hard for the average surfer to avoid them.

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How To Grow New Organs

Image: "Microfabrication Of Three-Dimensional Engineered Scaffolds," By Jeffrey T. Borenstein, Eli J. Weinberg, Brian K. Orrick, Cathryn Sundback, Mohammad R. Kaazempur-Mofrad And Joseph P. Vacanti, In TISSUE ENGINEERING, Vol. 13, No. 8; 2007

From Scientific American:

Pioneers in building living tissue report important advances over the past decade.

Key Concepts

* Efforts to build living tissue replacements have progressed over the past decade, and some simple engineered tissues are already used in humans.
* Advances have come from a greater understanding of cell behavior and sophisticated new building materials.
* More tissue-engineered products are close to commercial readiness but must undergo the complex regulatory scrutiny given to living materials.

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A Potential Breakthrough In Harnessing the Sun’s Energy

From environment360:

New solar thermal technology overcomes a major challenge facing solar power – how to store the sun’s heat for use at night or on a rainy day. As researchers tout its promise, solar thermal plants are under construction or planned from Spain to Australia to the American Southwest.

In the high desert of southern Spain, not far from Granada, the Mediterranean sun bounces off large arrays of precisely curved mirrors that cover an area as large as 70 soccer fields. These parabolic troughs follow the arc of the sun as it moves across the sky, concentrating the sun’s rays onto pipes filled with a synthetic oil that can be heated to 750 degrees Fahrenheit. That super-heated oil is used to boil water to power steam turbines, or to pump excess heat into vats of salts, turning them a molten, lava-like consistency.

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