A New Class of Antibiotics Could Offer Hope Against TB

Indian Tuberculosis (TB) patients stand in a queue for sputum collection at a Tuberculosis Treatment Centre in New Delhi. Manan Vatsyayana / AFP / Getty

From Time Magazine:

Eighty years after the discovery of penicillin, researchers say they are on the verge of developing a new class of antibiotics.

Publishing in the Oct. 17 issue of the journal Cell, scientists at Rutgers University describe a group of antibiotic compounds, first isolated decades ago from naturally occurring antibacterial substances in soil. Among them, researchers say, is a compound called myxopyronin that shows great promise. It has been synthesized in the lab and shown to be safe in animal trials, and although the drug hasn't been tested in humans yet, cell-based experiments suggest that it is potent enough to kill a wide range of stubborn bugs, including drug-resistant strains of tuberculosis and the deadly type of staph known as MRSA.

The Rutgers research reflects a much-needed, if slow, renewal of scientific interest in antibiotics development. The last two decades of the 20th century saw nearly zero progress, and in those years several disease-causing bacteria evolved resistance to commonly used drugs. Researchers at the Centers for Disease Control and Prevention found that more than 40% of staph infections in the U.S. in 2006 were MRSA — a bug that now kills more Americans a year than AIDS. Today, the first line of treatment against MRSA is vancomycin, a formidable antibiotic that has been around since the 1950s and is otherwise typically considered a drug of last resort. In the developing world, health workers report a proliferation of XDR (extensively drug-resistant) and MDR (multidrug-resistant) tuberculosis, against which the current first-line antibiotics, rifamycins, developed in the 1960s, have also become useless.

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NASA Launches Probe To Study Edge Of Solar System

File picture shows shows an ultraviolet image of the sun in something approaching "true color". NASA on Sunday launched a probe into space on a two-year mission to study the distant edge of the solar system. (AFP/NASA/File/Michael Benson)

From Yahoo News/AP:

WASHINGTON (AFP) – NASA on Sunday launched a probe into orbit high above earth to study the distant edge of the solar system where hot solar winds crash into the cold outer space.

The Interstellar Boundary Explorer (IBEX) was launched at 1745 GMT, according to images broadcast live by the US space agency.

The small probe was deployed on a Pegasus rocket which dropped from the bay doors of a Lockheed L-1011 jet flying at 12,000 meters (40,000 feet) over the southern Pacific Ocean near the Marshall Islands.

"The count went really smooth... and everything appears to be going well," NASA assistant launch manager Omar Baez said shortly after the launch.

The IBEX is on a two-year mission to take pictures and chart the mysterious confines of the solar system -- including areas billions of kilometers (miles) from earth.

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Black And White TV Generation Have Monochrome Dreams

From The Telegraph/Science:

Do you dream in black and white? If so, the chances are you are over 55 and were brought up watching a monochrome television set.

New research suggests that the type of television you watched as a child has a profound effect on the colour of your dreams.

While almost all under 25s dream in colour, thousands of over 55s, all of whom were brought up with black and white sets, often dream in monchrome - even now.

The findings suggest that the moment when Dorothy passes out of monochrome Kansas and awakes in Technicolor Oz may have had more significance for our subconscious than we literally ever dreamed of.

Eva Murzyn, a psychology student at Dundee University who carried out the study, said: "It is a fascinating hypothesis.

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The Passenger Jet That Just Missed Colliding With A UFO 22,000ft Above Kent

From Daily Mail:

As the captain of Flight AZ 284 began his descent into Heathrow, he saw something alarming overhead.

Shaped like a missile, the object suddenly veered across the airliner's path causing the pilot to shout 'Look out!' as he attempted to avert a mid-air collision 22,000ft above the Kent countryside.

Travelling at an estimated 120mph, it passed less than 1,000ft from the passenger jet before disappearing from radar screens, leaving the pilot and accident investigators baffled.

Secret documents released for the first time reveal that Ministry of Defence staff accept that an Unidentified Flying Object zooming above Lydd caused the nearmiss.

The incident took place at 7.58pm on April 21, 1991, and was investigated by the Civil Aviation Authority and military experts.

Having ruled out the possibility of it being a missile, weather balloon or space rocket, the MoD was forced to conclude that it was a genuine UFO and close the inquiry.

The unexplained close encounter is one of many recounted in military UFO documents released today by the National Archives.

The Alitalia aircraft was on a routine flight from Milan to Heathrow with 57 people on board when the ten-foot long object, which had no exhaust flame, was spotted by pilot Achille Zaghetti.

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More Problems With Hubble

Hubble Telescope

From Science News:

Hubble’s resurrection is suspended while engineers examine two anomalies
Two anomalies onboard the orbiting Hubble Space Telescope, which stopped transmitting data on September 27, caused engineers to suspend re-activation of Hubble’s science equipment. Engineers encountered problems following an intricate maneuver to circumvent a piece of failed hardware. Hubble is currently orbiting Earth in a dormant “safe mode” while the malfunctions are assessed.

In an October 17 teleconference, NASA scientists said that it is too soon to know the details of the failures. “We are in the early stages of going through a mountain of data that has been downloaded,” said Art Whipple, manager of the Hubble Systems Management Office at NASA’s Goddard Space Flight Center in Greenbelt, Md., at the teleconference. “This is a marathon, not a sprint.”

These latest anomalies came at a critical time, during the team’s attempt on October 16 to wake up all of Hubble’s science equipment and restore the orbiting telescope to full science capabilities.

The late September failure in Hubble’s science data formatting unit halted all science data communications to Earth. Since then, Hubble has been orbiting Earth silently, performing only basic health and safety functions, with almost all of its science observations suspended.

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Space Expectations

THE MIND OF WERNHER VON BRAUN: In the October 18, 1952, issue of Collier's, von Braun sketched out the 190-foot- (58-meter-) tall "orbit-to-orbit space ship," which he designed to transport people from a space station to lunar orbit.

From Scientific American:

German rocket physicist and astronautics engineer Wernher von Braun played a crucial role in developing the rocket technology, including the Saturn 5 , that put U.S. astronauts on the surface of the moon in 1969. Just 17 years earlier, when spaceflight was little more than a dream, von Braun worked for the U.S. Army building ballistic missiles. It was during this time that the future and first director of NASA's Marshall Space Flight Center in Huntsville, Ala., would share his vision of manned space exploration. A series of articles published in Collier's magazine in the early 1950s revealed many ideas that later became reality (including space stations, lunar missions and satellites) and some that never got off the ground (a rocket operated by three rhesus monkeys).

Von Braun's sketches for the magazine's illustrations are up for bid by U.K. auctioneers Bonhams Wednesday. The auction house, which expected the lot of 35 drawings and letters to fetch up to $25,000, was pleasantly surprised with the winning bid came in at $132,000.

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Genetic-based Human Diseases Are An Ancient Evolutionary Legacy, Research Suggests

Artistic illustration of a phylostratigraphy.
(Credit: Irena Andreic, Ruđer Bošković Institute, Zagreb)

From Space Daily:

ScienceDaily (Oct. 19, 2008) — Tomislav Domazet-Lošo and Diethard Tautz from the Max Planck Institute for Evolutionary Biology in Plön, Germany, have systematically analysed the time of emergence for a large number of genes - genes which can also initiate diseases. Their studies show for the first time that the majority of these genes were already in existence at the origin of the first cells.

The search for further genes, particularly those which are involved in diseases caused by several genetic causes, is thus facilitated. Furthermore, the research results confirm that the basic interconnections are to be found in the function of genes - causing the onset of diseases - can also be found in model organisms (Molecular Biology and Evolution).

The Human Genome Project that deciphered the human genetic code, uncovered thousands of genes that, if mutated, are involved in human genetic diseases. The genomes of many other organisms were deciphered in parallel. This now allows the evolution of these disease associated genes to be systematically studied.

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Monopoly Brings Out the Worst in People

From Live Science:

Last weekend we had some folks over to play Monopoly. There were four adults and three kids, and we all wanted some family fun.

It's always chancy playing board games with good friends because people with dice in their hands, even very nice, mild mannered people, often turn cutthroat.

With this group, it started as the parents set up the board and the kids ran around.

Half the parents, it seemed, wanted to make sure our fiscally innocent children were protected from unscrupulous players. "Let's let the kids win," said one mother.

But the other parents didn’t give a hoot about the kids. "It's their fault if they don't understand economics. Let's take them for all they've got," said one father.

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Men's Reactions Peak At Age 39

From Live Science:

This explains everything.

Scientists asked 72 men, ranging in age from 23 to 80, to tap their index fingers as fast as they could for 10 seconds. The researchers also did brain scans to measure in each subject the amount of myelin — a fatty sheath of insulation that coats nerve axons and allows for signaling bursts in our brains.

Both the tapping speed and the amount of myelin was found to decline "with an accelerating trajectory" after age 39.

Study leader George Bartzokis, professor of psychiatry at UCLA, called the results "pretty striking" and said: "That may well be why, besides achy joints and arthritis, even the fittest athletes retire and all older people move slower than they did when they were younger."

The myelination of brain circuits was known to peak in middle age. Bartzokis and others have long argued that brain aging might be primarily related to the myelin breakdown.

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Could Solar Power Satellites Beam Down Gigawatts of Energy?

Image from NASA

From Treehugger:

How pie-in-the-sky is Ben Bova's space satellite scheme? Mr. Bova, the president emeritus of the National Space Society and a prolific science fiction author, penned a column in last Sunday's Washington Post calling on the next president to build an armada of solar power satellites (SPS) -- basically large accumulations of solar cells -- to help meet a substantial chunk of our energy needs. The idea of building orbiting solar systems in space is nothing new (see my posts about Japan's Space Solar Power Systems and India's space plans); the concept, as described by its creator, aerospace engineer Peter Glaser, would be a satellite in high orbit (where sunshine is always present) that would use microwave transmission to beam solar power to receiving stations on Earth.

The obvious benefit: a continuous 24-hour, 365-day supply of solar energy. Powered by solar energy itself, a single SPS could generate up to 10 gigawatts of power continually, according to Bova. If that's even remotely true, just imagine how much continuous power a group of these SPSs could provide.

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Protective Shield Of The Sun Is Shrinking

From The Sydney Morning Herald:

LONDON: The protective bubble around the sun that helps to shield the Earth from harmful interstellar radiation is shrinking and getting weaker, NASA scientists have discovered.

New data from the Ulysses deep-space probe show that the heliosphere, the protective shield of energy that surrounds our solar system, has weakened by 25 per cent over the past decade and is now at it lowest level since the space race began 50 years ago.

Scientists, baffled at what could be causing the barrier to shrink in this way, were set to launch a mission overnight to study the heliosphere.

The Interstellar Boundary Explorer, or Ibex, will orbit 240,000 kilometres above the Earth and "listen" for the shock wave that forms as our solar system meets interstellar radiation.

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The Final Frontier: An Essay By Stephen Hawkings

From Cosmos Magazine:

In the 1960s the space race created a fascination with science and great technological advances. To find alien life we need to take back up that mantle, says astrophysicist Stephen Hawking, and send people further into space.

Why should we go into space? What is that justification for spending all that effort and money on getting a few lumps of Moon rock? Aren't there better causes here on Earth?

In a way, the situation was like that in Europe before 1492. People might well have argued that it was a waste of money to send Columbus on a wild goose chase over an almost unimaginable distance. Yet, the discovery of the New World made a profound difference to the old one.

Spreading out into space will have an even greater effect; it will completely change the future of the human race and maybe determine whether we have any future at all.

It won't solve many of our immediate problems on Earth, but it will give us a new perspective on them and cause us to look both outwards and inwards. With luck it could unite us to face a common challenge.

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Man's Oldest friend: Scientists Discover The Grandad O Modern Dogs... From 31,700 Years Ago

A Siberian husky, thought to most resemble the Paleolithic dogs of our forefathers
(Photo from Daily Mail)

From Daily Mail:

For hundreds of years they've been considered man's best friend, and now it seems dogs have been around longer than thought.

Scientists have discovered the oldest-ever remains of dogs dating back 31,700 years - that's 221,900 in dog years...

The remains push back the date for the earliest dog by 14,000 years, and suggest the forefathers of the modern canine were a lot stronger and a lot hungrier than next-door's Fido.

From studying the fossils, found at Goyet Cave in Belgium, the international team of scientists believe the animals subsisted on a diet of horse, musk ox and reindeer.

Lead author Mietje Germonpré, a paleontologist at the Royal Belgian Institute of Natural Sciences, said: 'In shape, the Paleolithic dogs most resemble the Siberian husky, but in size, however, they were somewhat larger, probably comparable to large shepherd dogs.

'The Paleolithic dogs had wider and shorter snouts and relatively wider brain cases than fossil and recent wolves.'

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Colossal Black Holes Common In Early Universe, Spectacular Galactic Collision Suggests

Artist’s conception of the 4C60.07 system of colliding galaxies. The galaxy on the left has turned most of its gas into stars, and the black hole in its center is ejecting charged particles in the two immense jets shown. The galaxy on the right also has a black hole causing the galaxy’s central region to shine, but much of its light is hidden by surrounding gas and dust. Vast numbers of stars are forming out of the gas and dust, and some of the material is being pulled away from the galaxy. (Credit: David A. Hardy/UK ATC)

From Science Daily:

ScienceDaily (Oct. 16, 2008) — Astronomers think that many - perhaps all - galaxies in the universe contain massive black holes at their centers. New observations with the Submillimeter Array now suggest that such colossal black holes were common even 12 billion years ago, when the universe was only 1.7 billion years old and galaxies were just beginning to form.

The new conclusion comes from the discovery of two distant galaxies, both with black holes at their heart, which are involved in a spectacular collision.

4C60.07, the first of the galaxies to be discovered, came to astronomers' attention because of its bright radio emission. This radio signal is one telltale sign of a quasar - a rapidly spinning black hole that is feeding on its home galaxy.

When 4C60.07 was first studied, astronomers thought that hydrogen gas surrounding the black hole was undergoing a burst of star formation, forming stars at a remarkable rate - the equivalent of 5,000 suns every year. This vigorous activity was revealed by the infrared glow from smoky debris left over when the largest stars rapidly died.

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Awesome Pictures Of The Sun

Boston.com published some great pictures of the Sun. The link is HERE.

The Power Of Music

(Image from University of East Anglia)

Amazing Power of Music Revealed -- Live Science

More than 7,000 runners who raced earlier this month in a half-marathon in London were under the influence of a scientifically derived and powerful performance-enhancing stimulant — pop music.

The dance-able, upbeat music at London's "Run to the Beat" race was selected on the basis of the research and consultation of sport psychologist Costas Karageorghis of Brunel University in England. He has learned how to devise soundtracks that are just as powerful, if not more so, as some of the not-so-legal substances that athletes commonly take to excel.

"Music is a great way to regulate mood both before and during physical activity. A lot of athletes use music as if it's a legal drug," Karageorghis told LiveScience. "They can use it as a stimulant or as a sedative. Generally speaking, loud upbeat music has a stimulating effect and slow music reduces arousal."

The link between music and athletic performance is just one example of the inroads scientists and doctors are making into understanding the amazing power that music has over our minds and bodies. Science is backing up our intuition and experience, showing that music really does kill pain, reduce stress, better our brains and basically change how we experience life.

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Even Moderate Alcohol Seems To Shrink Brain

Image from Sottish Youth Parliament

From Future Pundit:

Using 1,839 subjects in the Framingham Offspring Study examined with functional magnetic resonance imagining (fMRI) researchers find that even lower levels of alcohol drinking are associated with more rapid brain shrinkage with age.

Increasing alcohol intake was associated with loss in total brain volume greater than expected from age alone (P<0.001), reported Carol Ann Paul, of Wellesley College, and colleagues in the October issue of the Archives of Neurology. In the cross-sectional study, women were affected more strongly than men by moderate alcohol intake averaging one to two drinks a day (eight to 14 per week). Do you drink two drinks a day? If so, you are probably getting dumber faster than you need to. The hope was that cardiovascular benefits of moderate alcohol consumption would keep the brain better fed with blood and slow brain aging. But that hope seems unrealistic now. The cardiovascular benefits of low to moderate alcohol intake are thought to result from increasing blood flow rates, which would have been expected to benefit the brain also, Paul said. But rather than preventing normal age-related volume reductions, the effects of moderate drinking were closer to those of heavy drinking, which has been linked to brain atrophy and cognitive decline, the researchers noted.

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World's Hottest Ever Planet Is Discovered - At A Sizzling 2250C It's Half As Hot As The Sun!

Hottest ever: The new planet is half the temperature of the Sun (Image from the Daily Mail)

From The Daily Mail:

Scientists have made an amazing discovery in space - the hottest ever planet ever found.

The planet, known as WASP-12b, is believed to be an amazing 2250 Centigrade, about half as hot as the Sun.

The planet, which one and half times the size of Jupiter, orbits at one fortieth the distance between the Earth and the Sun.

Despite the mind-boggling temperature of the new planet, it may not necessarily keep hold of its record for long. Wasp-12b only just edges out the last record-holder HD 149026b, which is a searing 2040 Centigrade.

The discovery was made using two sets of telescopes, one in Spain's Canary Islands and the other in South Africa, to search for signs of 'transiting' planets, which pass in front of and dim their host stars as seen from Earth.

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Reading This Will Change Your Brain

Jeff Sherman / Taxi-Getty Images (Photo from Newsweek)

From Newsweek:

A leading neuroscientist says processing digital information can rewire your circuits. But is it evolution?

Is technology changing our brains? A new study by UCLA neuroscientist Gary Small adds to a growing body of research that says it is. And according to Small's new book, "iBRAIN: Surviving the Technological Alteration of the Modern Mind," a dramatic shift in how we gather information and communicate with one another has touched off an era of rapid evolution that may ultimately change the human brain as we know it. "Perhaps not since early man first discovered how to use a tool has the human brain been affected so quickly and so dramatically," he writes. "As the brain evolves and shifts its focus towards new technological skills, it drifts away from fundamental social skills."

The impact of technology on our circuitry should not come as a surprise. The brain's plasticity—it's ability to change in response to different stimuli—is well known. Professional musicians have more gray matter in brain regions responsible for planning finger movements. And athletes' brains are bulkier in areas that control hand-eye coordination. That's because the more time you devote to a specific activity, the stronger the neural pathways responsible for executing that activity become. So it makes sense that people who process a constant stream of digital information would have more neurons dedicated to filtering that information. Still, that's not the same thing as evolution.

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Mysterious Cyclones Seen At Both of Saturn's Poles

From National Geographic:

Saturn boasts cyclones at each of its poles that dramatically outpower Earth-roving hurricanes, new images reveal.

The Cassini spacecraft—a cooperative project of NASA, the European Space Agency, and the Italian Space Agency—recently peered below what had previously appeared to be isolated cumulus clouds at the planet's south pole.

"What looked like puffy clouds in lower resolution images are turning out to be deep convective structures seen through the atmospheric haze," Cassini imaging team member Tony Del Genio said in a press release.

"One of them has punched through to a higher altitude and created its own little vortex."

"Little" is relative—the eye of the storm is surrounded by an outer ring of clouds that measures 2,500 miles (4,000 kilometers) wide. That's about five times the size of the largest cyclones, or hurricanes, on Earth.

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