Swine Flu Program Could Be Largest Vaccination Effort In Human History

You Might Feel A Little Pinch

From Popular Science:

With the White House Council of Advisors on Science and Technology estimating that this winter's swine flu outbreak could lead to 30,000 to 90,000 deaths in the US (on top of the usual 30,000 deaths that occur from seasonal flu), the government has ramped up its effort to vaccinate as many Americans as possible against H1N1. In fact, the vaccination effort is so large, it may constitute the largest vaccination program in human history.

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Universal Vaccine Could Put An End To All Flu

From New Scientist:

IT IS not a nice way to die. As the virus spreads through your lungs, your immune system goes into overdrive. Your lungs become leaky and fill with fluid. Your lips and nails, then your skin, turn blue as you struggle to get enough oxygen. Basically, you drown.

Flu can kill in other ways, too, from rendering you vulnerable to bacterial infections to triggering heart attacks. Of course, most flu strains, including (so far) the 2009 pandemic virus, cause only mild symptoms in the vast majority of people. But with 10 to 20 per cent of people worldwide getting flu every year, that still adds up to a huge burden of illness - and even in a good year some half a million die.

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Swine Flu: How Experts Are Preparing Their Families

How will the health infrastructure cope? (Image: Raveendran/AFP/Getty

From New Scientist:

AS THE swine flu pandemic continues to sweep the world, what do public health officials, epidemiologists and flu researchers think will happen in the coming months? When New Scientist asked 60 of them, it turned out that half are concerned enough about the possibility of a virulent swine flu outbreak to take precautions such as acquiring a supply of Tamiflu for their families. Though most do not think it likely that a nastier strain will emerge, many are worried that if it did, their local hospitals and other parts of the health infrastructure could not cope.

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The Flu Hunters: Racing To Outsmart A Pandemic

Research student Nick Cattle, working in the flu lab at the World Influenza Centre
Philip Hollis for TIME

From Time Magazine:

On April 25, Rod Daniels, the deputy director of the World Influenza Centre in London, was at a meeting in Germany when he received a call from a co-worker: an influenza outbreak had been reported in Mexico and the first samples of the virus were on their way to London for examination. A virologist who has studied flu for more than 30 years, Daniels knew exactly what he was looking for. Influenza A viruses — the type that can cause pandemics — use a protein called hemagglutinin to bind to the cells of their animal hosts. When a virus jumps from animals to humans, its contagiousness is largely determined by what is called the "binding specificity" of this protein. An alpha-2,3 binding specificity means the virus is well suited to the cells in an animal respiratory tract but probably not human cells. An alpha-2,6 binding specificity, on the other hand, means the virus can easily bind to human cells.

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Swine Flu: 'Tamiflu Harm Outweighs Benefits For Children'

Their study found that Tamiflu caused vomiting in some children, which can lead to dehydration and complications Photo: REUTERS

From The Telegraph:

Children should not be given the anti-viral drug Tamiflu for swine flu because its harms outweigh any benefits, Oxford researchers have said.

They called on the Department of Health to have an urgent rethink of its current policy in the swine flu pandemic.

Their study found that Tamiflu caused vomiting in some children, which can lead to dehydration and complications.

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Why Are Flu Viruses Seasonal?

Heide Benser / Corbis

From Time Magazine:

U.S. health officials are bracing for a resurgence of the new H1N1/09 flu virus this fall, when the influenza season kicks into high gear with the resurgence of cold weather. By October, the government hopes to have 120 million doses of vaccine ready to fight the new virus, which is currently spreading around the world in the first pandemic in more than 40 years. Already, H1N1 is hitting the southern hemisphere hard: Argentina has recorded more than 160 deaths from H1N1, second most after the U.S. That's because it's winter in the southern hemisphere, and flu infections tend to spike during the fall and winter months in temperate countries.

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Swine Flu Vaccine 'By September'

From the BBC:

The first swine flu vaccines are likely to be licensed for use in the general population in September, the World Health Organization has announced.

Several manufacturers have produced initial batches of a H1N1 vaccine and some clinical trials are already underway.

WHO director of vaccine research Dr Marie-Paule Kieny also sought to calm fears about safety of new vaccines.

She said the vaccines were based on "old and proven technology".

Figures show continuing rises in cases in the southern hemisphere in the past seven days.

Argentina has particularly seen a large increase and deaths now stand at 337.

And there has been a rise in cases of 25% in Australia.

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WHO Maintains 2 Bln Estimate For Likely H1N1 Cases

From Reuters:

* Rough estimate of likely H1N1 cases by end is 2 billion

* No precise estimate of current infections

* High proportion of southern hemisphere flu cases are H1N1

* WHO to update on vaccine efforts this week

* WHO names African expert as H1N1 chief

By Jonathan Lynn

GENEVA, Aug 4 (Reuters) - The World Health Organisation stuck on Tuesday to its statement that about two billion people could catch H1N1 influenza by the time the flu pandemic ends.

But the estimate comes with a big health warning: no one knows how many people so far have caught the new strain, known as swine flu, and the final number will never be known as many cases are so mild they may go unnoticed.

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Who Should Get the H1N1 Vaccine First?

A doctor at the Centers for Disease Control examines specimens in an effort to develop new influenza vaccines. James Gathany / CDC / Reuters

From Time Magazine:

World health officials are carefully watching the H1N1/09 swine flu virus as it makes it way through the Southern Hemisphere, which is currently in the thick of its flu season. They are particularly interested in seeing how severely the virus affects infected people in parts of Africa, South America and Australia, since their illnesses could be a good predictor of how aggressive the virus will be when flu season returns to the rest of the world in the fall.

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Australia's Swine Flu Fight Holds Lessons For World, Say Scientists

Credit: AFP

From COSMOS:

MELBOURNE: Hard-hit Australia has become a global case study for swine flu, with Europe and the United States watching closely as it battles the disease in the southern hemisphere winter.

The outbreak began here in early May, as Australia was entering its annual flu season, speeding up infections so much that in a month Melbourne was the world's 'swine flu capital' with the highest number of cases per capita in the world.

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New Flu Treatment Outsmarts Mutations

Candy Coated: A new treatment targets “lollipop” molecules on the flu’s surface. Russell Kightley/Photo Researchers

From Popsci.com:

A new drug could foil any outbreak.

Before swine flu swept through the U.S., the virus had bounced around South America undetected for years. The H1N1 strain caught scientists by surprise, and without a vaccine. But a few weeks before the first North American case popped up, researchers successfully tested a therapy that could knock out almost any flu, and possibly any virus.

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Tracking The Evolution Of A Pandemic

Photo: Birth of a bug: New research on the emergence of the 1918 influenza virus suggests that it may have evolved in a manner similar to that of the current H1N1 strain (shown here). Credit: Center for Disease Control and Prevention

From The Technology Review:

Understanding how viruses evolve could help predict the next outbreak.

A close examination of the genetic evolution of the three major influenza epidemics of the 20th century concludes that all of the viruses involved evolved slowly, through interspecies genetic exchange, and that genes from the catastrophic 1918 pandemic may have been circulating as many as seven years earlier. If true, this means that widespread genetic surveillance methods should have ample time to detect the next pandemic strain, and possibly even vaccinate against it before it gets out of control.

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H1N1 (Swine Flu) News Updates -- July 14, 2009

Swine flu experts have warned the virus could become more deadly.
Photograph: AP

New Flu "Unstoppable", WHO Says, Calls For Vaccine -- Reuters

WASHINGTON (Reuters) - Saying the new H1N1 virus is "unstoppable", the World Health Organization gave drug makers a full go-ahead to manufacture vaccines against the pandemic influenza strain on Monday and said healthcare workers should be the first to get one.

Every country will need to vaccinate citizens against the swine flu virus and must choose who else would get priority after nurses, doctors and technicians, said Dr. Marie-Paule Kieny, WHO director of the Initiative for Vaccine Research.

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More News On H1N1

New flu resembles feared 1918 virus: study -- Reuters
U.K. Aims for Broad Vaccination Program -- Wall Street Journal
WHO warns of vaccine shortfall for coming flu season -- Globe And Mail
Swine flu: health experts 'surprised' by spread of virus in the UK -- The Guardian
NHS helplines swamped as swine flu panic rises after death of six-year-old girl -- Daily Mail
67 Air Force cadets stricken with swine flu -- Denver Post/AP

Revealed: How Pandemic Swine Flu Kills

From The New Scientist:

As the H1N1 swine flu pandemic continues to spread around the world, most cases are still mild. But reports are starting to emerge of people who sicken and die very quickly of what appears to be viral pneumonia. Now two independent groups of scientists have now found out why – and it's all down to where the virus binds within the body.

H1N1 swine flu comes from pigs, so it binds well to cell-surface molecules in the respiratory tracts of other mammals, including humans. But there are slight differences in the way different flu proteins bind to these receptors.

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Swine Flu 'Shows Drug Resistance'

From The BBC:

Experts have reported the first case of swine flu that is resistant to tamiflu - the main drug being used to fight the pandemic.

Roche Holding AG confirmed a patient with H1N1 influenza in Denmark showed resistance to the antiviral drug.

David Reddy, company executive, said it was not unexpected given that common seasonal flu could do the same.

The news comes as a nine-year-old girl has become the third to die in the UK with swine flu.

It is understood from her doctors at Birmingham Children's Hospital that she had underlying health conditions. It is not yet known whether swine flu contributed to her death.

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Swine Flu 'Could Infect Up To Half The Population'

A medical researcher working to produce a DNA test for swine flu, which is spreading more quickly in the UK. Photo AFP.

From The Independent:

Health authorities told to set up testing and drug distribution centres in case of autumn outbreak.

Primary care trusts are to set up anti-viral drug distribution centres and swine flu testing clinics amid fears that the infection could spread out of control.

The Chief Medical Officer, Sir Liam Donaldson, wrote to health authorities last week urging hospitals to test all patients who show signs of flu-like symptoms. He wrote: "Transmission from person to person in this country is increasingly common. There is evidence that sporadic cases are arising with no apparent link either to cases elsewhere in the UK or to travel abroad."

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Remaining H1N1 Questions

From Time:

The H1N1 flu seems a far cry from the mass killer it was feared to be when it first emerged in Mexico in April. While it has since infected more than 12,000 people in 43 countries, including more than 6,500 in the U.S., it has so far killed just 86 victims. Health officials are still on high alert, however; the disease continues to spread, with a batch of new cases in Japan in mid-May that could be enough to prompt the World Health Organization (WHO) to declare an official pandemic.

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'New' Brazilian Flu Strain Is A False Alarm

From New Scientist:

Take a jumpy media, throw in a statement hastily translated from Portuguese, and what have you got? A "new" and potentially deadly strain of H1N1 influenza in Brazil, according to a rash of news stories that appeared earlier today.

"It was not yet known whether the new strain was more aggressive than the current A(H1N1) virus which has been declared pandemic by the World Health Organization," reported Agence France Presse, setting the mood for a new round of pandemic panic.

But this "new" strain is nothing of the sort. In fact, the sequence of its gene for the haemagglutinin surface protein, deposited in the GenBank database, is the same as isolates from several other countries. "[It] has nothing surprising about it and is identical to others," Richard Webby of St Jude Children's Research Hospital in Memphis, Tennessee, told New Scientist.

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