Coffee 'May Reverse Alzheimer's'

From The BBC:

Drinking five cups of coffee a day could reverse memory problems seen in Alzheimer's disease, US scientists say.

The Florida research, carried out on mice, also suggested caffeine hampered the production of the protein plaques which are the hallmark of the disease.

Previous research has also suggested a protective effect from caffeine.

But British experts said the Journal of Alzheimer's disease study did not mean that dementia patients should start using caffeine supplements.

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Why Chimps, Monkeys Don't Develop Alzheimer's

This April 29, 2009 photo shows 'Jody,' a chimpanzee who was used for breeding and biomedical research at Chimpanzee Sanctuary Northwest in Cle Elum, Wash. As attacks and other problems with privately owned chimpanzees make the news, some chimpanzee sanctuaries are seeing an increase in inquiries from pet owners, looking for help in caring for their animals. (AP Photo/Ted S. Warren)

From Yahoo News/Healthday:

MONDAY, May 25 (HealthDay News) -- Scientists have long noticed a curious phenomenon among primates: Humans get the devastating neurological disorder known as Alzheimer's disease, but their closest evolutionary cousins don't.

Even more inexplicable is the fact that chimpanzee and other non-human primate brains do get clogged with the same protein plaques that are believed by many to cause the disease in humans.

The answer to this puzzle could yield valuable insight into how Alzheimer's develops and progresses, and now researchers report they may have a clue. They report their finding in the latest issue of the journal Neurobiology of Aging.

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Trial Drugs 'Reverse' Alzheimer's

From The BBC:

US scientists say they have successfully reversed the effects of Alzheimer's with experimental drugs.

The drugs target and boost the function of a newly pinpointed gene involved in the brain's memory formation.

In mice, the treatment helped restore long-term memory and improve learning for new tasks, Nature reports.

The same drugs - HDAC inhibitors - are currently being tested to treat Huntington's disease and are on the market to treat some cancers.

They reshape the DNA scaffolding that supports and controls the expression of genes in the brain.

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Early Warning Clue For Dementia

From BBC:

Heightened activity in an area of the brain that deals with memory may give a subtle early warning of dementia decades later, UK research suggests.

It was known that carrying a rogue version of a gene called ApoE4 raised the risk of Alzheimer's disease.

Now researchers have linked the same mutation with raised activity in an area of the brain called the hippocampus in people as young as 20.

The study appears in Proceedings of the National Academy of Science.

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Slow Starvation of Brain Triggers Alzheimer's

A 3-D image of brain atrophy differences in mild cognitive impairment (MCI) patients and mild Alzheimer's disease patients. Alzheimer's patients show far more damage overall, especially in cortical areas of the brain. Credit: Dr. Liana G. Apostolova, David Geffen School of Medicine at UCLA

From Live Science:

A slow starvation of the brain over time is one of the major triggers of the biochemistry that causes some forms of Alzheimer's, according to a new study that is helping to crack the mystery of the disease's origins.

An estimated 10 million baby boomers will develop Alzheimer's in their lifetime, according to the Alzheimer's Association. The disease usually begins after age 60, and risk rises with age. The direct and indirect cost of Alzheimer's and other dementias is about $148 billion a year.

Robert Vassar of Northwestern University, the study's lead author, found that when the brain doesn't get enough of the simple sugar called glucose — as might occur when cardiovascular disease restricts blood flow in arteries to the brain — a process is launched that ultimately produces the sticky clumps of protein that appear to be a cause of Alzheimer's.

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Strong Education Blunts Effects Of Alzheimer's Disease, Study Suggests

Some people who appeared to have the brain plaques long associated with Alzheimer's disease nonetheless received high scores on tests of their cognitive ability. Participants who did well on the tests were likely to have spent more years in school. (Credit: iStockphoto/Don Bayley)

From Science Daily:

ScienceDaily (Nov. 11, 2008) — A test that reveals brain changes believed to be at the heart of Alzheimer's disease has bolstered the theory that education can delay the onset of the dementia and cognitive decline that are characteristic of the disorder.

Scientists at the Alzheimer's Disease Research Center at Washington University School of Medicine in St. Louis found that some study participants who appeared to have the brain plaques long associated with Alzheimer's disease still received high scores on tests of their cognitive ability. Participants who did well on the tests were likely to have spent more years in school.

"The good news is that greater education may allow people to harbor amyloid plaques and other brain pathology linked to Alzheimer's disease without experiencing decline of their cognitive abilities," says first author Catherine Roe, Ph.D., research instructor in neurology.

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Vitamin B Supplements Could Prevent Alzheimer's Memory Loss

From The Telegraph:

Patients with Alzheimer's disease have been given fresh hope as scientists discover that off the shelf vitamin B supplement halts memory loss.

Researchers have discovered that high doses of Vitamin B3, which costs as little as £4 over the counter, could have a dramatic effect on the onslaught of the progressive disease.

The breakthrough by US scientists could mean a cheap and easily obtainable treatment for the 417,000 or so sufferers in the UK.

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